{"metadata":{"accession":"Q1LUT2","id":"Q1LUT2_DANRE","source_organism":{"taxId":"7955","scientificName":"Danio rerio","fullName":"Danio rerio (Zebrafish)"},"name":"DNA topoisomerase 2","description":["Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand"],"length":1618,"sequence":"MSNGAAGSGGLTWVTLFDKNNGAKKEEMNGRGDAGKSEVVKKESSKKMSVERIYQKKTQLEHILLRPDTYIGSVEPVTQQMWVFDEEIGMNLREISFVPGLYKIFDEILVNAADNKQRDKNMTTIKITIDPESNTISVWNNGKGIPVVEHKDEKMYVPALIFGHLLTSSNYDDNEKKVTGGRNGYGAKLCNIFSLKFTVETACKEYKRSFKQTWTENMGKSNEAKIKYFDGEDFTCVTFQPDLAKFNMEKLDKDIVALLTRRAYDVAGSCRGVKVILNGKKLPVNSFRSYVDFYVKDKLDETGVALKVVNETVNERWEVCLTMSEKGFQQISFVNSIATTKGGRHIDYIVDQIVGKLIEVVKKKNKAGVSVKPFQVKNHLWVFVNALIENPTFDSQTKENMTLQTKSFGSKCALSEKFIRAATNCGIVESILNWVKFKAQTQLNKKCSSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREATHKQIMENAEINNIIKILGLQYKKSYDDPESLKSLRYGRIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEEFITPIVKASKNKQEVSFYSIPEFEEWKKHTESYKTWHIKYYKGLGTSTSKEAKEYFSDMERHRIMFKYNGTEDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEQYLYGTSTRHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCVKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPAVDSSLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLNHQDPLPMLPSYKNFKGTIHELGQNQYLVSGEVSVLDKNTIEISELPVRTWTQAYKESVLEPMLQGTDKTPPLISDYKEYHTDTTVKFVVRMTEEKLAQAEAAGLHKVFKLQSSLTCNSMVLFDHMGCMKRYESVQEILKEFFELRLHYYKLRKDWLVGSLGAESAKLSNQARFVLEKIEGKLSIENKSKRDLIRMLVQRGYESDPVAAWNKAQEKSLEEEDGGGNDSDSSVDSGSFSGPNFNYILNMPLWCLTKEKVEELLKQRDLKKAELNELQSKTSENLWREDLAVFIEELDRVEEQEKESVNLGKAVKLVKGKVGKPKVKKMQLEETLPSPFGRRVEPQITLAMKADASKKLTKKKKGEIDAAVKLEIDDDSALGSNGGENSLISPSGLPNPGAKPKAPRVKREKKEPGTPRQRKPAGAKGPAKKVKKRNPWSDDDEGGDDDRSDIELDECEPVIPRDSTSRRASAVKAKYTFDFSEEEEEEEDGDEEQENDASASPVHSFKNTEQHDDEVDDDDDIFPPKTTFTLPTSTAKKKNPEPVLPSKTTYDDKISDDDMKSDSDGDRGPVFSSYSSSSAFEKPAKKTAKKPVDTPPKPKKAPVKAKKPDTSVWDSDSDTGTKKPPASKGSGKGRSKKRKQSSLEEDEYSPMKKHGKSATSRKPKKAASDDEDDDDDDETGFNSFSHLDSGRDRSGRAKKEVKYFAESDNDDDDDMFD","proteome":"UP000000437","gene":"top2b","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003918","name":"DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006265","name":"DNA topological change","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006259","name":"DNA metabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"168092c496ae46f2c3e92c2fab72b16f7b9c4e1b","counters":{"domain_architectures":1526,"entries":47,"isoforms":0,"proteomes":1,"sets":7,"structures":0,"taxa":1,"dbEntries":{"ssf":3,"cathgene3d":7,"cdd":4,"pfam":6,"smart":3,"profile":2,"panther":1,"prints":2,"prosite":1,"interpro":18},"proteome":1,"taxonomy":1,"similar_proteins":1526}}}