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{
    "metadata": {
        "accession": "M4ANX8",
        "id": "M4ANX8_XIPMA",
        "source_organism": {
            "taxId": "8083",
            "scientificName": "Xiphophorus maculatus",
            "fullName": "Xiphophorus maculatus (Southern platyfish)"
        },
        "name": "Endothelin-1",
        "description": [
            "Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Also binds the DEAR/FBXW7-AS1 receptor. Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments. NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2"
        ],
        "length": 197,
        "sequence": "MWSHRNRIHAQLRFLCGLFLISQKMDFKLWISALCVTLCAALCAPAAGTRSAAPASAQRHVRNKRCSCATFLDKECVYFCHLDIIWVNTPERVVSYGLGNAPRAKRDLSVSTATTRAPRCRCLHGNDSSCVNFCLRSEMTTGARIRSPGHARTDDTGEPDRPEGVFGAVRRIRLLLEKWPARRRHRAGAWQGESAAS",
        "proteome": "UP000002852",
        "gene": null,
        "go_terms": [
            {
                "identifier": "GO:0019229",
                "name": "regulation of vasoconstriction",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0005576",
                "name": "extracellular region",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "78237e3573ff557c191d81c9b102247786fa0748",
        "counters": {
            "domain_architectures": 2874,
            "entries": 8,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 0,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "smart": 1,
                "panther": 1,
                "pfam": 1,
                "prosite": 1,
                "prints": 1,
                "interpro": 3
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 2874
        }
    }
}