{"metadata":{"accession":"M4ANX8","id":"M4ANX8_XIPMA","source_organism":{"taxId":"8083","scientificName":"Xiphophorus maculatus","fullName":"Xiphophorus maculatus (Southern platyfish)"},"name":"Endothelin-1","description":["Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Also binds the DEAR/FBXW7-AS1 receptor. Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments. NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2"],"length":197,"sequence":"MWSHRNRIHAQLRFLCGLFLISQKMDFKLWISALCVTLCAALCAPAAGTRSAAPASAQRHVRNKRCSCATFLDKECVYFCHLDIIWVNTPERVVSYGLGNAPRAKRDLSVSTATTRAPRCRCLHGNDSSCVNFCLRSEMTTGARIRSPGHARTDDTGEPDRPEGVFGAVRRIRLLLEKWPARRRHRAGAWQGESAAS","proteome":"UP000002852","gene":null,"go_terms":[{"identifier":"GO:0019229","name":"regulation of vasoconstriction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005576","name":"extracellular region","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"78237e3573ff557c191d81c9b102247786fa0748","counters":{"domain_architectures":2874,"entries":8,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"smart":1,"panther":1,"pfam":1,"prosite":1,"prints":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":2874}}}