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{
    "metadata": {
        "accession": "M3ZEN5",
        "id": "M3ZEN5_XIPMA",
        "source_organism": {
            "taxId": "8083",
            "scientificName": "Xiphophorus maculatus",
            "fullName": "Xiphophorus maculatus (Southern platyfish)"
        },
        "name": "Calcitonin gene-related peptide type 1 receptor",
        "description": [
            "G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway",
            "May function as G protein-coupled receptor for calcitonin-gene-related peptides and adrenomedullin. Specificity may be modulated by accessory proteins. May activate cAMP-dependent pathway"
        ],
        "length": 806,
        "sequence": "MRCAGSWWIVWSLLVLREAADAGTIADASLSPGLSTKMGQSEKALSQGQHRCVEPSKRDAQENRTGLFCAPMWDGFLCWNETPAGESVTLQCPDHPDLGPTEKITKYCDKSGNWVQTGSACGPPLKSKIEEISFLKDAAGEPTTEAMWVRTEKIILENENKCLEKMKNAPPYNKSGLHCSRNWDGWLCWDDTPAGSYASQNCPDYFVNFDRTEQAKKYCGADGEWFRHPASNKIWTNYTLCVTTDDKRPAKLKVEENEQKCLQKMKQDPALNKTAPYCSRNWDGWLCWDDTPAGTLASQSCPDYFSDLNPTAMATKYCAEDGQWFRHPASSTTWTNYTLCVDDNPEILRATAQFSRNTEVDLISEATESPEVQQKNREIVRRKILDNQYKCFEKINRDPPYNKSGLYCSRNWDGWLCWEDTPAGTYTFQNCPNYFDDFDPTEKATKYCGEDGQWFRHPDTNRTWSNYTLCNENTKAKLKSAYILFYMAIVGHALSIASLLISLAIFFYFRSLSCQRITLHKNLFCSYVLNSALTIIYLVTVVNNPKVVASNPVSCKVLHFFHMYMLGCNYFWMLCEGIYLHTLIVVAVFAEEQHLHWYYLLGWGFPLVPVSIHAVARKKYFDDNCWMSVETHLLYAVHGPIVAALLVNLFFLLNIIRVLVTKLRDTHRAESNMYMKAVRATLILVPLLGIQFVIFPWRPENRLAGEVYEYVMHILMHYQGLLVATIFCFFNGEVQAALKRQWMQYKTQWGQRRKDHCSMRSTSYTATSITEVPAFMYHHECNAEHLNGCHTKDSELVALKSGDTYA",
        "proteome": "UP000002852",
        "gene": null,
        "go_terms": [
            {
                "identifier": "GO:0004930",
                "name": "G protein-coupled receptor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0007186",
                "name": "G protein-coupled receptor signaling pathway",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0004888",
                "name": "transmembrane signaling receptor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0007166",
                "name": "cell surface receptor signaling pathway",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0004948",
                "name": "calcitonin receptor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "8b3023afc54f20161816ef8cca660605c12f5498",
        "counters": {
            "domain_architectures": 106,
            "entries": 24,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "ssf": 2,
                "profile": 2,
                "smart": 1,
                "cdd": 1,
                "pfam": 2,
                "panther": 1,
                "prints": 3,
                "prosite": 2,
                "interpro": 8
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 106
        }
    }
}