{"metadata":{"accession":"M3ZEN5","id":"M3ZEN5_XIPMA","source_organism":{"taxId":"8083","scientificName":"Xiphophorus maculatus","fullName":"Xiphophorus maculatus (Southern platyfish)"},"name":"Calcitonin gene-related peptide type 1 receptor","description":["G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway","May function as G protein-coupled receptor for calcitonin-gene-related peptides and adrenomedullin. Specificity may be modulated by accessory proteins. May activate cAMP-dependent pathway"],"length":806,"sequence":"MRCAGSWWIVWSLLVLREAADAGTIADASLSPGLSTKMGQSEKALSQGQHRCVEPSKRDAQENRTGLFCAPMWDGFLCWNETPAGESVTLQCPDHPDLGPTEKITKYCDKSGNWVQTGSACGPPLKSKIEEISFLKDAAGEPTTEAMWVRTEKIILENENKCLEKMKNAPPYNKSGLHCSRNWDGWLCWDDTPAGSYASQNCPDYFVNFDRTEQAKKYCGADGEWFRHPASNKIWTNYTLCVTTDDKRPAKLKVEENEQKCLQKMKQDPALNKTAPYCSRNWDGWLCWDDTPAGTLASQSCPDYFSDLNPTAMATKYCAEDGQWFRHPASSTTWTNYTLCVDDNPEILRATAQFSRNTEVDLISEATESPEVQQKNREIVRRKILDNQYKCFEKINRDPPYNKSGLYCSRNWDGWLCWEDTPAGTYTFQNCPNYFDDFDPTEKATKYCGEDGQWFRHPDTNRTWSNYTLCNENTKAKLKSAYILFYMAIVGHALSIASLLISLAIFFYFRSLSCQRITLHKNLFCSYVLNSALTIIYLVTVVNNPKVVASNPVSCKVLHFFHMYMLGCNYFWMLCEGIYLHTLIVVAVFAEEQHLHWYYLLGWGFPLVPVSIHAVARKKYFDDNCWMSVETHLLYAVHGPIVAALLVNLFFLLNIIRVLVTKLRDTHRAESNMYMKAVRATLILVPLLGIQFVIFPWRPENRLAGEVYEYVMHILMHYQGLLVATIFCFFNGEVQAALKRQWMQYKTQWGQRRKDHCSMRSTSYTATSITEVPAFMYHHECNAEHLNGCHTKDSELVALKSGDTYA","proteome":"UP000002852","gene":null,"go_terms":[{"identifier":"GO:0004930","name":"G protein-coupled receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0007186","name":"G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004888","name":"transmembrane signaling receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007166","name":"cell surface receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004948","name":"calcitonin receptor activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"8b3023afc54f20161816ef8cca660605c12f5498","counters":{"domain_architectures":106,"entries":24,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"profile":2,"smart":1,"cdd":1,"pfam":2,"panther":1,"prints":3,"prosite":2,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":106}}}