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{
    "metadata": {
        "accession": "M3Y9Q9",
        "id": "M3Y9Q9_MUSPF",
        "source_organism": {
            "taxId": "9669",
            "scientificName": "Mustela putorius furo",
            "fullName": "Mustela putorius furo (European domestic ferret)"
        },
        "name": "Lipid droplet-regulating VLDL assembly factor AUP1",
        "description": [
            "Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Plays a role in lipid droplet formation. Induces lipid droplet clustering. Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation. Also required for the degradation of INSIG1, SREBF1 and SREBF2. Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB"
        ],
        "length": 410,
        "sequence": "MDPSHALGPERLFDSHRLPGDGFLLLALLLYAPVGFCLLVLRLFLGIHVFLVSCALPDSVLRRFVVRTMCAVLGLVARQEDSGLRDHRVRVLISNHVTPFDHNIVNLLTSCSTPLLNSPPSFVCWSRGFMEMDGRGELVESLKRFCASTRVPPTPLLLFPEEEATNGREGLLRFSSWPFSIQDVVQPLTLRVQRPLVSVTVSDASWVSELLWSLFVPFTVYQVRWLPPVHRQLGEGNEEFALRVQQLVAKELGQTGTRLTPADKAEHMKRQRHPRLRPQSAQSSFPPSPGPSPDVQLATLAQRVKEVLPHVPLGVIQRDLARTGCVDLTITNLLEGAVAFMPEDITEGTQSLPTASAPKFPSSGPVTPQPTALTFAKSSWARQESLQERKQALYEYARRRFTERQAQEAD",
        "proteome": "UP000000715",
        "gene": "AUP1",
        "go_terms": [
            {
                "identifier": "GO:0043130",
                "name": "ubiquitin binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0036503",
                "name": "ERAD pathway",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "6a1420a2d828932f2dc809150049cfa63156530f",
        "counters": {
            "domain_architectures": 15330,
            "entries": 9,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 1,
                "cathgene3d": 1,
                "smart": 1,
                "profile": 1,
                "cdd": 1,
                "pfam": 1,
                "panther": 1,
                "interpro": 2
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 15330
        }
    }
}