{"metadata":{"accession":"M3Y9Q9","id":"M3Y9Q9_MUSPF","source_organism":{"taxId":"9669","scientificName":"Mustela putorius furo","fullName":"Mustela putorius furo (European domestic ferret)"},"name":"Lipid droplet-regulating VLDL assembly factor AUP1","description":["Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Plays a role in lipid droplet formation. Induces lipid droplet clustering. Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation. Also required for the degradation of INSIG1, SREBF1 and SREBF2. Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB"],"length":410,"sequence":"MDPSHALGPERLFDSHRLPGDGFLLLALLLYAPVGFCLLVLRLFLGIHVFLVSCALPDSVLRRFVVRTMCAVLGLVARQEDSGLRDHRVRVLISNHVTPFDHNIVNLLTSCSTPLLNSPPSFVCWSRGFMEMDGRGELVESLKRFCASTRVPPTPLLLFPEEEATNGREGLLRFSSWPFSIQDVVQPLTLRVQRPLVSVTVSDASWVSELLWSLFVPFTVYQVRWLPPVHRQLGEGNEEFALRVQQLVAKELGQTGTRLTPADKAEHMKRQRHPRLRPQSAQSSFPPSPGPSPDVQLATLAQRVKEVLPHVPLGVIQRDLARTGCVDLTITNLLEGAVAFMPEDITEGTQSLPTASAPKFPSSGPVTPQPTALTFAKSSWARQESLQERKQALYEYARRRFTERQAQEAD","proteome":"UP000000715","gene":"AUP1","go_terms":[{"identifier":"GO:0043130","name":"ubiquitin binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0036503","name":"ERAD pathway","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"6a1420a2d828932f2dc809150049cfa63156530f","counters":{"domain_architectures":15330,"entries":9,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"smart":1,"profile":1,"cdd":1,"pfam":1,"panther":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":15330}}}