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{
    "metadata": {
        "accession": "I1TMG8",
        "id": "I1TMG8_9BETC",
        "source_organism": {
            "taxId": "31632",
            "scientificName": "Rat coronavirus",
            "fullName": "Rat coronavirus"
        },
        "name": "Hemagglutinin-esterase",
        "description": [
            "Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. May become a target for both the humoral and the cellular branches of the immune system"
        ],
        "length": 437,
        "sequence": "MGRMCIAMAPRTLLLLIGCQLVFGFNEPINIVSHLNDDWFLFGDSRSDCTYVENNGHPKLDWLDLDPKLCNSGKIAAKSGNSLFRSFHFTDFYNYTGEGDQIIFYEGVNFSPSHGFKCLVEGDNNKWMGNKARFYALLYKKMAQYRSLSFVTVPYAYGGNAKPTSICKDKTLTLNNPTFISKESVDYYYVSEANFTLQGCDEFIVPLCVFNGHSRGSSSDPANKYYTDSQSYYNIDTGVLYGFNSTLDVGNTAQNPGLDLTCMYLVLTPGNYKAVSLEYLLTIPSKAICLRKPKRFMPVQVVDSRWNSTRQSDNMTAVACQLPYCFFRNTSADYSGDTHDVHHGDFYFRQLLSGLLYNVSCIAQQGAFLYNNVSSIWPVYGYGHCPTAANIGYMAPVCLYDPLPVILLGVLLGIAVLIIVFLILYFMADSSVRLHEA",
        "proteome": null,
        "gene": "HE",
        "go_terms": [
            {
                "identifier": "GO:0016788",
                "name": "hydrolase activity, acting on ester bonds",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0046789",
                "name": "host cell surface receptor binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0019064",
                "name": "fusion of virus membrane with host plasma membrane",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0019031",
                "name": "viral envelope",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0001681",
                "name": "sialate O-acetylesterase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": false,
        "in_bfvd": false,
        "ida_accession": "23ed7ca7d20282f2438938d9dcba003c67d90e8b",
        "counters": {
            "domain_architectures": 474,
            "entries": 9,
            "isoforms": 0,
            "proteomes": 0,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 2,
                "pfam": 2,
                "hamap": 1,
                "interpro": 4
            },
            "proteome": 0,
            "taxonomy": 1,
            "similar_proteins": 474
        }
    }
}