{"metadata":{"accession":"I1TMG8","id":"I1TMG8_9BETC","source_organism":{"taxId":"31632","scientificName":"Rat coronavirus","fullName":"Rat coronavirus"},"name":"Hemagglutinin-esterase","description":["Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. May become a target for both the humoral and the cellular branches of the immune system"],"length":437,"sequence":"MGRMCIAMAPRTLLLLIGCQLVFGFNEPINIVSHLNDDWFLFGDSRSDCTYVENNGHPKLDWLDLDPKLCNSGKIAAKSGNSLFRSFHFTDFYNYTGEGDQIIFYEGVNFSPSHGFKCLVEGDNNKWMGNKARFYALLYKKMAQYRSLSFVTVPYAYGGNAKPTSICKDKTLTLNNPTFISKESVDYYYVSEANFTLQGCDEFIVPLCVFNGHSRGSSSDPANKYYTDSQSYYNIDTGVLYGFNSTLDVGNTAQNPGLDLTCMYLVLTPGNYKAVSLEYLLTIPSKAICLRKPKRFMPVQVVDSRWNSTRQSDNMTAVACQLPYCFFRNTSADYSGDTHDVHHGDFYFRQLLSGLLYNVSCIAQQGAFLYNNVSSIWPVYGYGHCPTAANIGYMAPVCLYDPLPVILLGVLLGIAVLIIVFLILYFMADSSVRLHEA","proteome":null,"gene":"HE","go_terms":[{"identifier":"GO:0016788","name":"hydrolase activity, acting on ester bonds","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0046789","name":"host cell surface receptor binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019064","name":"fusion of virus membrane with host plasma membrane","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0019031","name":"viral envelope","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0001681","name":"sialate O-acetylesterase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"23ed7ca7d20282f2438938d9dcba003c67d90e8b","counters":{"domain_architectures":474,"entries":9,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"pfam":2,"hamap":1,"interpro":4},"proteome":0,"taxonomy":1,"similar_proteins":474}}}