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{
    "metadata": {
        "accession": "G5BN50",
        "id": "G5BN50_HETGA",
        "source_organism": {
            "taxId": "10181",
            "scientificName": "Heterocephalus glaber",
            "fullName": "Heterocephalus glaber (Naked mole rat)"
        },
        "name": "TBC1 domain family member 7",
        "description": [
            "Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1"
        ],
        "length": 293,
        "sequence": "MTEDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDIEKLCTFSQRFPLPSMYRALVWKVLLGILPPHHESHTQVMMYHKDQYCDVLHGLKVIRFVSDATPQVEVYLRMYQLESGKLPRSPSFRLEPEDEVFLAIAKAMEEMVEDSVDCYWIIRCFVNQLNNKYRDSLPQLPKALEQYLNLEDGRLLSHLKSCSAVSKLPCDLWFKRCFAGCLPASSLQRQVVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSPEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVH",
        "proteome": null,
        "gene": "GW7_13041",
        "go_terms": null,
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": true,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "0f758f40e90632dd313394a84749246bb3624026",
        "counters": {
            "domain_architectures": 67568,
            "entries": 11,
            "isoforms": 0,
            "proteomes": 0,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 3,
                "ssf": 1,
                "profile": 1,
                "panther": 1,
                "pfam": 1,
                "interpro": 4
            },
            "proteome": 0,
            "taxonomy": 1,
            "similar_proteins": 67568
        }
    }
}