{"metadata":{"accession":"G5BN50","id":"G5BN50_HETGA","source_organism":{"taxId":"10181","scientificName":"Heterocephalus glaber","fullName":"Heterocephalus glaber (Naked mole rat)"},"name":"TBC1 domain family member 7","description":["Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1"],"length":293,"sequence":"MTEDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDIEKLCTFSQRFPLPSMYRALVWKVLLGILPPHHESHTQVMMYHKDQYCDVLHGLKVIRFVSDATPQVEVYLRMYQLESGKLPRSPSFRLEPEDEVFLAIAKAMEEMVEDSVDCYWIIRCFVNQLNNKYRDSLPQLPKALEQYLNLEDGRLLSHLKSCSAVSKLPCDLWFKRCFAGCLPASSLQRQVVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSPEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVH","proteome":null,"gene":"GW7_13041","go_terms":null,"protein_evidence":4,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"0f758f40e90632dd313394a84749246bb3624026","counters":{"domain_architectures":67568,"entries":11,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":1,"profile":1,"panther":1,"pfam":1,"interpro":4},"proteome":0,"taxonomy":1,"similar_proteins":67568}}}