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{
    "metadata": {
        "accession": "G3TKN6",
        "id": "G3TKN6_LOXAF",
        "source_organism": {
            "taxId": "9785",
            "scientificName": "Loxodonta africana",
            "fullName": "Loxodonta africana (African elephant)"
        },
        "name": "Serine protease HTRA2, mitochondrial",
        "description": [
            "Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6. Cleaves THAP5 and promotes its degradation during apoptosis"
        ],
        "length": 457,
        "sequence": "MAALRAGRGAGWSLRGLRALGGIRCGKGSLLTPDLRALLTSGTPDPRARVTYGTSNLRARLSAGVPEPPACLTSGTPDSRARLTAEIPDPQTREASGTPGTRPRVWLAVALGAGGAVLLLWGGGRGPPAVLAAVSDPPPTSPRSQYNFIADVVEKTAPAVVYIEILGRHPFSSREVPISNGSGFVVAADGLIVTNAHVVADRRHVRVRLPSGDTYEAMVTAVDPVADIATLRIQTEEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLRRGEKKNSLFGVSGSQRRYIGVMMLTLTPSILAELQLREPNFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQLVQNAEDVYEAVRTQSQLAVRIRRGPETLTLYVTPEVTE",
        "proteome": "UP000007646",
        "gene": "HTRA2",
        "go_terms": [
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0004252",
                "name": "serine-type endopeptidase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006508",
                "name": "proteolysis",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "a91117da869a35547876bcc310da68b803a7d944",
        "counters": {
            "domain_architectures": 4109,
            "entries": 16,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "ssf": 2,
                "pfam": 2,
                "cdd": 1,
                "smart": 1,
                "profile": 1,
                "panther": 1,
                "prints": 1,
                "interpro": 5
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 4109
        }
    }
}