{"metadata":{"accession":"G3TKN6","id":"G3TKN6_LOXAF","source_organism":{"taxId":"9785","scientificName":"Loxodonta africana","fullName":"Loxodonta africana (African elephant)"},"name":"Serine protease HTRA2, mitochondrial","description":["Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6. Cleaves THAP5 and promotes its degradation during apoptosis"],"length":457,"sequence":"MAALRAGRGAGWSLRGLRALGGIRCGKGSLLTPDLRALLTSGTPDPRARVTYGTSNLRARLSAGVPEPPACLTSGTPDSRARLTAEIPDPQTREASGTPGTRPRVWLAVALGAGGAVLLLWGGGRGPPAVLAAVSDPPPTSPRSQYNFIADVVEKTAPAVVYIEILGRHPFSSREVPISNGSGFVVAADGLIVTNAHVVADRRHVRVRLPSGDTYEAMVTAVDPVADIATLRIQTEEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLRRGEKKNSLFGVSGSQRRYIGVMMLTLTPSILAELQLREPNFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQLVQNAEDVYEAVRTQSQLAVRIRRGPETLTLYVTPEVTE","proteome":"UP000007646","gene":"HTRA2","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004252","name":"serine-type endopeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006508","name":"proteolysis","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a91117da869a35547876bcc310da68b803a7d944","counters":{"domain_architectures":4109,"entries":16,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"pfam":2,"cdd":1,"smart":1,"profile":1,"panther":1,"prints":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":4109}}}