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{
    "metadata": {
        "accession": "F6R5E1",
        "id": "F6R5E1_MONDO",
        "source_organism": {
            "taxId": "13616",
            "scientificName": "Monodelphis domestica",
            "fullName": "Monodelphis domestica (Gray short-tailed opossum)"
        },
        "name": "alpha-1,2-Mannosidase",
        "description": [
            "Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2"
        ],
        "length": 663,
        "sequence": "MQWKSLVLGLLLLRLGLHGALWLAFGLGPSMGFYQRFPISFGLQNLKGIEGRAASSAPPYWLGAPGVRGPQPSRRTPAEQSSRPEKGPGTPEPPGPGMCPKSYWASLLGGWAPGGGVDEYERRYSSAFPPQLRAQMRDLARGMFAFGYDNYMAHAFPEDELNPIHCRGRGPDRGNPSNVNINDVLGNYSLTLVDALDTLAIMGNSSEFQKAVKLVINTVSFDKDSTVQVFEATIRVLGSLLSAHRIITDSEQPFGDMTIKDYDNELLHMARDLALRLLPAFENTKTGIPYPRVNLKSGVPPDSNNETCTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWNLRSNYTGLLGNVINIQTGTWVGRQSGLGAGLDSFYEYLLKSYILFGEDDDLEMFNAAYRSIQTFLRRGRRACNEGEGDPPLYVNVNMFSGQMMNTWIDSLQAFFPGLQILIGDVENAICLHAFYYAIWKRFGALPERYNWQLQVPETPFYPLRPELVESTYLLYQATKNPFYLHVGMDILQSLEKHTKVKCGYATLHHVIEKSKEDRMESFFLSETCKYLYLLFDEENPVHQSGNGYMFTTEGHIISVDKYLRNSPWKKSLSEEEVGEHQEEKMSRSKPLELKVNTSGLNCNRIPDERRYSLPLKSIYMRQIDQMVGLI",
        "proteome": "UP000002280",
        "gene": "EDEM1",
        "go_terms": [
            {
                "identifier": "GO:0005975",
                "name": "carbohydrate metabolic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0004571",
                "name": "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005509",
                "name": "calcium ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:1904380",
                "name": "endoplasmic reticulum mannose trimming",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:1904382",
                "name": "mannose trimming involved in glycoprotein ERAD pathway",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "13d5268432f4d303731d0793ee3e5d7ec4e3887e",
        "counters": {
            "domain_architectures": 27413,
            "entries": 9,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "ssf": 1,
                "pfam": 1,
                "panther": 1,
                "prints": 1,
                "interpro": 4
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 27413
        }
    }
}