{"metadata":{"accession":"F6R5E1","id":"F6R5E1_MONDO","source_organism":{"taxId":"13616","scientificName":"Monodelphis domestica","fullName":"Monodelphis domestica (Gray short-tailed opossum)"},"name":"alpha-1,2-Mannosidase","description":["Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2"],"length":663,"sequence":"MQWKSLVLGLLLLRLGLHGALWLAFGLGPSMGFYQRFPISFGLQNLKGIEGRAASSAPPYWLGAPGVRGPQPSRRTPAEQSSRPEKGPGTPEPPGPGMCPKSYWASLLGGWAPGGGVDEYERRYSSAFPPQLRAQMRDLARGMFAFGYDNYMAHAFPEDELNPIHCRGRGPDRGNPSNVNINDVLGNYSLTLVDALDTLAIMGNSSEFQKAVKLVINTVSFDKDSTVQVFEATIRVLGSLLSAHRIITDSEQPFGDMTIKDYDNELLHMARDLALRLLPAFENTKTGIPYPRVNLKSGVPPDSNNETCTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWNLRSNYTGLLGNVINIQTGTWVGRQSGLGAGLDSFYEYLLKSYILFGEDDDLEMFNAAYRSIQTFLRRGRRACNEGEGDPPLYVNVNMFSGQMMNTWIDSLQAFFPGLQILIGDVENAICLHAFYYAIWKRFGALPERYNWQLQVPETPFYPLRPELVESTYLLYQATKNPFYLHVGMDILQSLEKHTKVKCGYATLHHVIEKSKEDRMESFFLSETCKYLYLLFDEENPVHQSGNGYMFTTEGHIISVDKYLRNSPWKKSLSEEEVGEHQEEKMSRSKPLELKVNTSGLNCNRIPDERRYSLPLKSIYMRQIDQMVGLI","proteome":"UP000002280","gene":"EDEM1","go_terms":[{"identifier":"GO:0005975","name":"carbohydrate metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004571","name":"mannosyl-oligosaccharide 1,2-alpha-mannosidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005509","name":"calcium ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:1904380","name":"endoplasmic reticulum mannose trimming","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:1904382","name":"mannose trimming involved in glycoprotein ERAD pathway","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"13d5268432f4d303731d0793ee3e5d7ec4e3887e","counters":{"domain_architectures":27413,"entries":9,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"panther":1,"prints":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":27413}}}