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{
    "metadata": {
        "accession": "F0LL89",
        "id": "F0LL89_THEBM",
        "source_organism": {
            "taxId": "391623",
            "scientificName": "Thermococcus barophilus (strain DSM 11836 / MP)",
            "fullName": "Thermococcus barophilus (strain DSM 11836 / MP)"
        },
        "name": "Reverse gyrase",
        "description": [
            "Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process, increasing the linking number in steps of +1. Binds to single-stranded DNA, transiently cleaves and then rejoins the ends, introducing a positive supercoil in the process. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate. Involved in rewinding DNA strands in regions of the chromosome that have opened up to allow replication, transcription, DNA repair and/or for DNA protection",
            "Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process, increasing the linking number in steps of +1. Binds to single-stranded DNA, transiently cleaves and then rejoins the ends, introducing a positive supercoil in the process. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate. Probably involved in rewinding DNA strands in regions of the chromosome that have opened up to allow replication, transcription, DNA repair and/or for DNA protection"
        ],
        "length": 1216,
        "sequence": "MKAIYREMCPNCEDRISDERLYKKHPCDVCLDREIQAEIYFDLITGIREALKLRRTLKHWENIYKLEKKLREIEDLFEKATGFNFWSAQKTWVKRLIKNKSFSIIAPTGMGKSVFGSFMALYYAKKKKKSYIVLPTTPLVVQTIKRVKTFAERAGIEINLAYYHGGMKKKEKEEMTEKIMSGDFDILITSAQWLARNFDEMLKDKRFDFIFVDDVDAFLKASKNIDRSLILLGFTEEIIQKAWEIIRLKKQMAKFLNGNSPDKQEQLKELNKQINKLEREIRKFKRENKIGVLIVASATGSARGDRIKLYRELLDFEVGSGRSALRNVVDSYLFPEKSIEEHVEELLTKLGKGGLIFVPIDQGISYAEKLTQYLQEKGFKVELVSARNKKGLEKFENEEIDYLVGVATYYGTIVRGLDLPHLIRYAIFTGVPKFRFSLDLEQPTIYRVLGLMSEVMEFLDEEDRREGERLYARLRRLIRNIPQFELMKIEEALAEGLPLEGFHSHVLEVFKQSVEFLRRVLKKEEVLKRIEEDPFVSLKEEEGKWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDNEKVFNGLKRQMRWRFAEFEMKPFEELNLEELLREIDSDREKVRLILAGKISEKTKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGDRMLTILASGGHMFDLVTTEGYHGVLIEERDGKLYFIPVYDTIKRCRDCGHQFVDWEERGVCPRCGSRNVRDALENVIAMREIAQEVDEILIGTDPDVEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKALNEARDVNEFRVNAQLVRRIEDRWIGFELSQKLWEVFESRNLSAGRVQTPVLGWVIQRYKEFVESETDFMALTLENGLSVTLEGVKDEVNEIIVEDVQIEEKEINPFPPYTTDTMLQDASRFLGFSAPHTMQLAQDLFELGLITYHRTDSTHVSNTGIEVAKEYISEEIGEEYFAPRKWGEEGAHECIRPTRPIDTGRLMQLLRDGIITLARGLTRDHFRLYDMIFKRFMASQMKAAKVLYEKAVIDARIAKTEIEGYVEIIFDGWTKLRAPPLKQLPRLEKGQKLKVIEVKKWRAPKVSLYTQGDLIALMKERKIGRPSTYAKIVKTLLDRHYVIETKGRKKLVPTELGTKVYHYLISKYKELVSEERTRQLEELMDLVEENKADYQEVLSNMYEEIKQYILK",
        "proteome": "UP000007478",
        "gene": "rgy",
        "go_terms": [
            {
                "identifier": "GO:0003676",
                "name": "nucleic acid binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005524",
                "name": "ATP binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0003916",
                "name": "DNA topoisomerase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006265",
                "name": "DNA topological change",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "3a26e0e3356a7336345ac099af0e7b55d795dd85",
        "counters": {
            "domain_architectures": 336,
            "entries": 41,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 7,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "profile": 5,
                "pfam": 4,
                "ssf": 2,
                "cathgene3d": 5,
                "cdd": 4,
                "smart": 4,
                "hamap": 1,
                "panther": 1,
                "ncbifam": 1,
                "prints": 1,
                "interpro": 13
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 336
        }
    }
}