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{
    "metadata": {
        "accession": "E8T6Y3",
        "id": "E8T6Y3_THEA1",
        "source_organism": {
            "taxId": "648996",
            "scientificName": "Thermovibrio ammonificans (strain DSM 15698 / JCM 12110 / HB-1)",
            "fullName": "Thermovibrio ammonificans (strain DSM 15698 / JCM 12110 / HB-1)"
        },
        "name": "DNA topoisomerase 1",
        "description": [
            "Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone"
        ],
        "length": 648,
        "sequence": "MLVIVESPTKAKKIQSFLGKGYTVKASLGHVRDLPPDEFAVSIEALEQGKFPFKFKVLAGKGRVVKELQRLASGELVLCASDPDREGEAIAWHLAQLLKEKAKEVKRIEFHEITKKALQEAVKRPREIDLNRVRAQFARRAIDRILGYLISPELSKELGKRGLSAGRVQSTALAEIVKREREIKEFVPKPYWVVEVELEKDGKKFRARTEKFWDKKEAQENLRFPTLLVIRADKRKKLEKPKAPFTASALQQEANRLFKWSPEYTMKVAQELFENGYITYHRSDSPRLSEEAVGFLRNLIPRLFGKDYLPAKPFVYKAKEGAQDAHEAIRPTKLTPEGAPENLKDRLTPQQLKLYTLIWKRTLASQMKEAVWNTQTVVLQNDRGVKFTAKGKTLVFEGWRKVYDAEVEEDGEGILPELRVGEKLPAKLRLKEDKTKPPARYTEGSLVKWLEKTGVGRPSTYASTVKTLKARKYVVVKGGKMVPTETAFRVIEFLEEKHPWILSPELTAQMEKQLDLVEQGKLDWRKPVLETVEKVRELLPLLSEERDDRPTEKQLEFARSLAEKLKKELPADVLLSKKKLSKWIDGAKRELAKEKANAPLSEKQVAVIEKHGDEKVREALLRGDYAYCRKWLDGFFRELKRSGRRKKK",
        "proteome": "UP000006362",
        "gene": "topA",
        "go_terms": [
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0003916",
                "name": "DNA topoisomerase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006265",
                "name": "DNA topological change",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0003917",
                "name": "DNA topoisomerase type I (single strand cut, ATP-independent) activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "50b5241a90332a8fc9fc2d4a42095c76d99ebd7a",
        "counters": {
            "domain_architectures": 15769,
            "entries": 30,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 3,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "profile": 2,
                "cathgene3d": 4,
                "smart": 3,
                "cdd": 2,
                "ssf": 1,
                "pfam": 2,
                "ncbifam": 1,
                "panther": 1,
                "hamap": 1,
                "prints": 1,
                "interpro": 12
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 15769
        }
    }
}