General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "E6TN14",
        "id": "E6TN14_MYCSR",
        "source_organism": {
            "taxId": "278137",
            "scientificName": "Mycolicibacterium gilvum (strain DSM 45189 / LMG 24558 / Spyr1)",
            "fullName": "Mycolicibacterium gilvum (strain DSM 45189 / LMG 24558 / Spyr1)"
        },
        "name": "Multifunctional 2-oxoglutarate metabolism enzyme",
        "description": [
            "Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which spontaneously decarboxylates to form 5-hydroxylevulinate (HLA). And is also a component of the 2-oxoglutarate dehydrogenase (ODH) complex, that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The KG decarboxylase and KG dehydrogenase reactions provide two alternative, tightly regulated, pathways connecting the oxidative and reductive branches of the TCA cycle"
        ],
        "length": 1283,
        "sequence": "MSSPSPFGQNEWLVEEMYRKFREDPSSVDPSWHEFLVDYSPEPTNEPATSTRPSSNGKPAAKAPTSPAEPAPAPKPTGTNGSTAPAKSDKPAAKSPEKPAAKSSSSEKPADKTAQKTTDKAAQKTESKTDGKSAEKAAPAKTSEKSAPAAASEDESQVLRGAAAAVVKNMSASLDVPTATSVRAIPAKAMIDNRIVINNHLKRTRGGKISFTHLLGYAIVQAVKKFPNMNRHFAEIDGKPNAVTPAHTNLGLAIDLPGKDGKRTLVVAAIKNCETMHFGQFIAAYEDIVRRARDGKLTGEDFAGVTISLTNPGTIGTVHSVPRLMQGQGAIVGAGAMEYPAEFQGASEERIAELGVGKLMTLTSTYDHRIIQGAESGDFLRTIHNLLLDDEFYDEIFRALGIPHEPVRWRIDNPDSIEDKNARVIELIAAYRNRGHLMADIDPLRLDKTRFRSHPDLDVNTHGLTLWDLDREFKVNGFAGQTNKKLRDILGLLRDAYCRHIGVEYTHILEPEQQQWLQDRIEIKHAKPTVAEQKYILSKLNAAEAFETFLQTKYVGQKRFSLEGAETVIPMMDAAIDQCAEHGLNEVVIGMPHRGRLNVLANIVGKPYSQIFTEFEGNLNPSQAHGSGDVKYHLGANGTYIQMFGDNDISVSLVANPSHLEAVDPVLEGIVRAKQDLLESGEEADGGAGDFTVVPMMLHGDAAFAGQGVVAETLNLALLRGYRTGGTIHIIVNNQIGFTTSPTDSRSSEYCTDVAKMIGAPIFHVNGDDPEAAVWVAKLAVDFRQKFKKDVVIDMLCYRRRGHNEGDDPSMTQPYMYDVIDTKRGVRKTYTEALIGRGDISMKEAEDALRDYQGQLERVFNEVRDLEKHEIEPSASVESDQMVPAGMKTAVDKSLLARVGDAHLAFGEDFNVHPRVKPVLEKRREMAYEGKVDWAFAELLALGTFLAEGKTIRFTGQDTRRGTFTQRHAVIIDRQSGREFTPLDLLTVDTDGNPTGGKLMIYDSALSEFAAVGFEYGYSVGNPNAMVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSDVVLLLPHGHEGQGPDHTSGRIERFLLLWAEGSMTIAVPSTPANYFHLLRRHGLDGIHRPLIVFTPKSMLRNKAAVSDLRDFTEAKFRSVLEEPTYTEGTGDRSKVTRVLLTCGKLYYELAARKSKQDRDDVAIVRLEQLAPLPKRRLAETLDQYPNAEKFFWVQEEPANQGAWPTLGLTLPEVLPDKLAGIKRISRRAMSAPSSGSSKVHAVEQQEIIDEAFA",
        "proteome": "UP000008916",
        "gene": "Mspyr1_16500",
        "go_terms": [
            {
                "identifier": "GO:0016746",
                "name": "acyltransferase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016624",
                "name": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0030976",
                "name": "thiamine pyrophosphate binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": false,
        "in_bfvd": false,
        "ida_accession": "c2c6f6420d261286b4efb7d3d1884412a4b080ae",
        "counters": {
            "domain_architectures": 3957,
            "entries": 27,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 4,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 5,
                "ssf": 2,
                "pfam": 5,
                "cdd": 1,
                "smart": 1,
                "ncbifam": 3,
                "panther": 1,
                "interpro": 9
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 3957
        }
    }
}