{"metadata":{"accession":"E6TN14","id":"E6TN14_MYCSR","source_organism":{"taxId":"278137","scientificName":"Mycolicibacterium gilvum (strain DSM 45189 / LMG 24558 / Spyr1)","fullName":"Mycolicibacterium gilvum (strain DSM 45189 / LMG 24558 / Spyr1)"},"name":"Multifunctional 2-oxoglutarate metabolism enzyme","description":["Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which spontaneously decarboxylates to form 5-hydroxylevulinate (HLA). And is also a component of the 2-oxoglutarate dehydrogenase (ODH) complex, that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The KG decarboxylase and KG dehydrogenase reactions provide two alternative, tightly regulated, pathways connecting the oxidative and reductive branches of the TCA cycle"],"length":1283,"sequence":"MSSPSPFGQNEWLVEEMYRKFREDPSSVDPSWHEFLVDYSPEPTNEPATSTRPSSNGKPAAKAPTSPAEPAPAPKPTGTNGSTAPAKSDKPAAKSPEKPAAKSSSSEKPADKTAQKTTDKAAQKTESKTDGKSAEKAAPAKTSEKSAPAAASEDESQVLRGAAAAVVKNMSASLDVPTATSVRAIPAKAMIDNRIVINNHLKRTRGGKISFTHLLGYAIVQAVKKFPNMNRHFAEIDGKPNAVTPAHTNLGLAIDLPGKDGKRTLVVAAIKNCETMHFGQFIAAYEDIVRRARDGKLTGEDFAGVTISLTNPGTIGTVHSVPRLMQGQGAIVGAGAMEYPAEFQGASEERIAELGVGKLMTLTSTYDHRIIQGAESGDFLRTIHNLLLDDEFYDEIFRALGIPHEPVRWRIDNPDSIEDKNARVIELIAAYRNRGHLMADIDPLRLDKTRFRSHPDLDVNTHGLTLWDLDREFKVNGFAGQTNKKLRDILGLLRDAYCRHIGVEYTHILEPEQQQWLQDRIEIKHAKPTVAEQKYILSKLNAAEAFETFLQTKYVGQKRFSLEGAETVIPMMDAAIDQCAEHGLNEVVIGMPHRGRLNVLANIVGKPYSQIFTEFEGNLNPSQAHGSGDVKYHLGANGTYIQMFGDNDISVSLVANPSHLEAVDPVLEGIVRAKQDLLESGEEADGGAGDFTVVPMMLHGDAAFAGQGVVAETLNLALLRGYRTGGTIHIIVNNQIGFTTSPTDSRSSEYCTDVAKMIGAPIFHVNGDDPEAAVWVAKLAVDFRQKFKKDVVIDMLCYRRRGHNEGDDPSMTQPYMYDVIDTKRGVRKTYTEALIGRGDISMKEAEDALRDYQGQLERVFNEVRDLEKHEIEPSASVESDQMVPAGMKTAVDKSLLARVGDAHLAFGEDFNVHPRVKPVLEKRREMAYEGKVDWAFAELLALGTFLAEGKTIRFTGQDTRRGTFTQRHAVIIDRQSGREFTPLDLLTVDTDGNPTGGKLMIYDSALSEFAAVGFEYGYSVGNPNAMVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSDVVLLLPHGHEGQGPDHTSGRIERFLLLWAEGSMTIAVPSTPANYFHLLRRHGLDGIHRPLIVFTPKSMLRNKAAVSDLRDFTEAKFRSVLEEPTYTEGTGDRSKVTRVLLTCGKLYYELAARKSKQDRDDVAIVRLEQLAPLPKRRLAETLDQYPNAEKFFWVQEEPANQGAWPTLGLTLPEVLPDKLAGIKRISRRAMSAPSSGSSKVHAVEQQEIIDEAFA","proteome":"UP000008916","gene":"Mspyr1_16500","go_terms":[{"identifier":"GO:0016746","name":"acyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016624","name":"oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0030976","name":"thiamine pyrophosphate binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"c2c6f6420d261286b4efb7d3d1884412a4b080ae","counters":{"domain_architectures":3957,"entries":27,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":5,"ssf":2,"pfam":5,"cdd":1,"smart":1,"ncbifam":3,"panther":1,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":3957}}}