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{
"metadata": {
"accession": "B8QUI1",
"id": "B8QUI1_HEV",
"source_organism": {
"taxId": "63421",
"scientificName": "Swine hepatitis E virus",
"fullName": "Swine hepatitis E virus"
},
"name": "Non-structural polyprotein pORF1",
"description": [
"Methyltransferase: Displays a capping enzyme activity. This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus. The enzymatic reaction involves a covalent link between 7-methyl-GMP and the methyltransferase, whereas eukaryotic capping enzymes form a covalent complex only with GMP. Methyltransferase catalyzes transfer of a methyl group from S-adenosylmethionine to GTP and GDP to yield m(7)GTP or m(7)GDP. GDP is a better substrate than GTP. This enzyme also displays guanylyltransferase activity to form a covalent complex, methyltransferase-m(7)GMP, from which 7-methyl-GMP is transferred to the mRNA to create the cap structure",
"NTPase/helicase: Multi-functional protein that exhibits NTPase and RNA unwinding activities. Hydrolyzes all NTPs efficiently and unwinds RNA duplexes containing 5' overhangs. Possesses a sequence independent RNA-5'-triphosphatase (RTPase) activity suggestive of its role in forming viral cap structure. Also participates in viral genome replication, RNA translocation and genome packaging/unpackaging",
"RNA-directed RNA polymerase: Plays an essential role in the virus replication. Binds to the 3'-end of the genomic RNA to initiate viral replication",
"Y-domain: Indispensable for virus replication"
],
"length": 1733,
"sequence": "MEAHQFIKAPGITTAIEQAALAAANSALANAVVVRPFLSRVQTDILINLMQPRQLVFRPEVLWNHPIQRVIHNELEQYCRARAGRCLEVGAHPRSINDNPNVLHRCFLRPVGRDVQRWYSAPTRGPAANCRRSALRGLPPVDRTYCFDGFSRCAFAAETGIALYSLHDLWPSDVAEAMARHGMTRLYAALHLPPEVLLPPGTYHTTSYLLIHDGNRAVVTYEGDTSAGYNHDVSILRAWIRTTKIVGDHPLVIERVRAIGCHFVLLLTAAPEPSPMPYVPYPRSTEVYVRSIFGPGGSPSLFPSACSTKSTFHAVPVHIWDRPMLFGATLDDQAFCCSRLMTYLRGISYKVTVGALVANEGWNASEDALTAVITAAYLTICHQRYLRTQAISKGMRRLEVEHAQKFITRLYSWLFEKSGRDYIPGRQLQFYAQCRRWLSAGFHLDPRVLVFDEAVPCRCRSFLKKAAGKFCCFMKWLGQECTCFLEPAEGLVGDCGHDNEAYEGSEVDPAEPAHLDVSGTYAVHGRQLEALYRALNIPDDIAARASRLTATVELAASPGRLECRTVLGNKTFRTSITDGAHLEANGPEQYVLTFDDSRQAMGAGPHSLTYELVPAGLQVKISSNGLDCTAIFPPGGAPSAAPSEVAAFCSALYRYNRFTQRHSLTGGLWLHPEGLLGLFPPFSPGHLWESANPFCGESTLYTRTWSTSGFSSDFSPPEAAYAAPVPDMGPPSGAPSSASDIWVLPPPSERSAIAPSPVAPVSKPANPPSLTTPRPPAREPPTPPPALTPVSDPANPSSPTTYKPPVRKPPTPPPARTRRLLYTYPDGAKVYAGSLFESDCDWLVNASNPGHRPGGGLCHAFYQRFPESFHPTDFVMREGLAAYTLSPRPIIHAVAPDYRVEQNPKRLEAAYRETCSRLGTAAYPLLGSGIYQAPVSLSFDAWERNHRPGDELYLTEPAAAWFEANKPTQPALTITEDAARTANLALEIDSATEVGRACAGCTINPGIVHYQFTAGVPGSGKSRSIQQGDVDVVVVPTRELRNSWRRRGFAAFTPHTAARVTAGRRVVIDEAPSLPPHLLLLHMQRASSVHLLGDPNQIPAIDFEHAGLVPAIRPELAPTSWWHVTHRCPADMCELIRGAYPKIQTTSRVLRSLFWNEPAVGQRLVFTQAAKAANPGAITVHEAQGATFTKTTIIATADARGLIQSSRAHAIVALTRHTEKCVILDAPGLLREVGISDIIVNNFFLAGGEVGHHRPSTIPRGNPDQNLDTLRAFPPSCQISAYHQLAEELGHRPAPVAAVLPPCPELEQGLLYMPQELTVSDSVLIFELTDIVHCRMAAPSQRKAVLSTLVGRYGRRTKLYEAAHSDVRESLGRFIPTIGPVQATTCELYELVEAMVEKGQDGSAVLELDLCSRDVSRITFFQKDCNKFTTGETIAHGKVGQGISAWSKTFCALFGPWFRAIEKEILALLPPNVFYGDAYEESVFSAAISGASSSMVFENDFSEFDSTQNNFSLGLECVIMEECGMPQWLIRLYHLVRSAWTLQAPKESLKGFWKKHSGEPGTLLWNTVWNMAIIAHCYEFRDLRVAAFKGDDSVVLCSDYRQSRNAATLIAGCGLKLKVDYRPIGLYAGVVVAPGLGALPDVVRFAGRLSEKNWGPGPERAEQLRLAVCDFLRGLTNVAQVCVDVVSRVYGVSPGLVHNLIGMLQTIADGKAHFTETVKPVLDLTNSIIQRLE",
"proteome": null,
"gene": null,
"go_terms": [
{
"identifier": "GO:0003723",
"name": "RNA binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0008174",
"name": "mRNA methyltransferase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006396",
"name": "RNA processing",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0016556",
"name": "mRNA modification",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0005524",
"name": "ATP binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0003968",
"name": "RNA-directed RNA polymerase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0039694",
"name": "viral RNA genome replication",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0019082",
"name": "viral protein processing",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0006351",
"name": "DNA-templated transcription",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"protein_evidence": 3,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": false,
"in_bfvd": false,
"ida_accession": "f4cab8d210f5bb9bf3bf6bcbb336a4b6bac78c2d",
"counters": {
"domain_architectures": 1,
"entries": 30,
"isoforms": 0,
"proteomes": 0,
"sets": 6,
"structures": 0,
"taxa": 1,
"dbEntries": {
"profile": 4,
"ssf": 3,
"cathgene3d": 2,
"smart": 1,
"cdd": 3,
"pfam": 5,
"interpro": 12
},
"proteome": 0,
"taxonomy": 1,
"similar_proteins": 1
}
}
}
