{"metadata":{"accession":"B8QUI1","id":"B8QUI1_HEV","source_organism":{"taxId":"63421","scientificName":"Swine hepatitis E virus","fullName":"Swine hepatitis E virus"},"name":"Non-structural polyprotein pORF1","description":["Methyltransferase: Displays a capping enzyme activity. This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus. The enzymatic reaction involves a covalent link between 7-methyl-GMP and the methyltransferase, whereas eukaryotic capping enzymes form a covalent complex only with GMP. Methyltransferase catalyzes transfer of a methyl group from S-adenosylmethionine to GTP and GDP to yield m(7)GTP or m(7)GDP. GDP is a better substrate than GTP. This enzyme also displays guanylyltransferase activity to form a covalent complex, methyltransferase-m(7)GMP, from which 7-methyl-GMP is transferred to the mRNA to create the cap structure","NTPase/helicase: Multi-functional protein that exhibits NTPase and RNA unwinding activities. Hydrolyzes all NTPs efficiently and unwinds RNA duplexes containing 5' overhangs. Possesses a sequence independent RNA-5'-triphosphatase (RTPase) activity suggestive of its role in forming viral cap structure. Also participates in viral genome replication, RNA translocation and genome packaging/unpackaging","RNA-directed RNA polymerase: Plays an essential role in the virus replication. Binds to the 3'-end of the genomic RNA to initiate viral replication","Y-domain: Indispensable for virus replication"],"length":1733,"sequence":"MEAHQFIKAPGITTAIEQAALAAANSALANAVVVRPFLSRVQTDILINLMQPRQLVFRPEVLWNHPIQRVIHNELEQYCRARAGRCLEVGAHPRSINDNPNVLHRCFLRPVGRDVQRWYSAPTRGPAANCRRSALRGLPPVDRTYCFDGFSRCAFAAETGIALYSLHDLWPSDVAEAMARHGMTRLYAALHLPPEVLLPPGTYHTTSYLLIHDGNRAVVTYEGDTSAGYNHDVSILRAWIRTTKIVGDHPLVIERVRAIGCHFVLLLTAAPEPSPMPYVPYPRSTEVYVRSIFGPGGSPSLFPSACSTKSTFHAVPVHIWDRPMLFGATLDDQAFCCSRLMTYLRGISYKVTVGALVANEGWNASEDALTAVITAAYLTICHQRYLRTQAISKGMRRLEVEHAQKFITRLYSWLFEKSGRDYIPGRQLQFYAQCRRWLSAGFHLDPRVLVFDEAVPCRCRSFLKKAAGKFCCFMKWLGQECTCFLEPAEGLVGDCGHDNEAYEGSEVDPAEPAHLDVSGTYAVHGRQLEALYRALNIPDDIAARASRLTATVELAASPGRLECRTVLGNKTFRTSITDGAHLEANGPEQYVLTFDDSRQAMGAGPHSLTYELVPAGLQVKISSNGLDCTAIFPPGGAPSAAPSEVAAFCSALYRYNRFTQRHSLTGGLWLHPEGLLGLFPPFSPGHLWESANPFCGESTLYTRTWSTSGFSSDFSPPEAAYAAPVPDMGPPSGAPSSASDIWVLPPPSERSAIAPSPVAPVSKPANPPSLTTPRPPAREPPTPPPALTPVSDPANPSSPTTYKPPVRKPPTPPPARTRRLLYTYPDGAKVYAGSLFESDCDWLVNASNPGHRPGGGLCHAFYQRFPESFHPTDFVMREGLAAYTLSPRPIIHAVAPDYRVEQNPKRLEAAYRETCSRLGTAAYPLLGSGIYQAPVSLSFDAWERNHRPGDELYLTEPAAAWFEANKPTQPALTITEDAARTANLALEIDSATEVGRACAGCTINPGIVHYQFTAGVPGSGKSRSIQQGDVDVVVVPTRELRNSWRRRGFAAFTPHTAARVTAGRRVVIDEAPSLPPHLLLLHMQRASSVHLLGDPNQIPAIDFEHAGLVPAIRPELAPTSWWHVTHRCPADMCELIRGAYPKIQTTSRVLRSLFWNEPAVGQRLVFTQAAKAANPGAITVHEAQGATFTKTTIIATADARGLIQSSRAHAIVALTRHTEKCVILDAPGLLREVGISDIIVNNFFLAGGEVGHHRPSTIPRGNPDQNLDTLRAFPPSCQISAYHQLAEELGHRPAPVAAVLPPCPELEQGLLYMPQELTVSDSVLIFELTDIVHCRMAAPSQRKAVLSTLVGRYGRRTKLYEAAHSDVRESLGRFIPTIGPVQATTCELYELVEAMVEKGQDGSAVLELDLCSRDVSRITFFQKDCNKFTTGETIAHGKVGQGISAWSKTFCALFGPWFRAIEKEILALLPPNVFYGDAYEESVFSAAISGASSSMVFENDFSEFDSTQNNFSLGLECVIMEECGMPQWLIRLYHLVRSAWTLQAPKESLKGFWKKHSGEPGTLLWNTVWNMAIIAHCYEFRDLRVAAFKGDDSVVLCSDYRQSRNAATLIAGCGLKLKVDYRPIGLYAGVVVAPGLGALPDVVRFAGRLSEKNWGPGPERAEQLRLAVCDFLRGLTNVAQVCVDVVSRVYGVSPGLVHNLIGMLQTIADGKAHFTETVKPVLDLTNSIIQRLE","proteome":null,"gene":null,"go_terms":[{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008174","name":"mRNA methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006396","name":"RNA processing","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016556","name":"mRNA modification","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003968","name":"RNA-directed RNA polymerase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0039694","name":"viral RNA genome replication","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0019082","name":"viral protein processing","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006351","name":"DNA-templated transcription","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"f4cab8d210f5bb9bf3bf6bcbb336a4b6bac78c2d","counters":{"domain_architectures":1,"entries":30,"isoforms":0,"proteomes":0,"sets":6,"structures":0,"taxa":1,"dbEntries":{"profile":4,"ssf":3,"cathgene3d":2,"smart":1,"cdd":3,"pfam":5,"interpro":12},"proteome":0,"taxonomy":1,"similar_proteins":1}}}