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{
    "metadata": {
        "accession": "A1DN30",
        "id": "NFSS_NEOFI",
        "source_organism": {
            "taxId": "331117",
            "scientificName": "Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)",
            "fullName": "Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)"
        },
        "name": "Sesterfisherol synthase",
        "description": [
            "Bifunctional terpene synthase; part of the gene cluster that mediates the biosynthesis of sesterfisheric acid (PubMed:26332841). The bifunctional terpene synthase NfSS converts dimethylallyl diphosphate (DMAPP) and isopentenyl diphosphate (IPP) into sesterfisherol (PubMed:26332841, PubMed:29410538). The C-terminal prenyltransferase (PT) domain of NfSS catalyzes formation of geranylfarnesyl pyrophosphate (GFPP), whereas the N-terminal terpene cyclase (TC) domain catalyzes the cyclization of GFPP to sesterfisherol (PubMed:26332841, PubMed:29410538). The cytochrome P450 monooxygenase NfP450 then catalyzes oxidative modifications of sesterfisherol into sesterfisheric acid (PubMed:26332841)"
        ],
        "length": 764,
        "sequence": "MEVWEHSRPIADDTIKKTPSFTTLPIRINKQNDVADAATRRALRDWDYYLHDGLAERALISISELGNLGAFAYPEVPPERLAIVTYLTDLGILHDDGYEAMDMDQARTEHREFGALFDPHEQLPSRRGTRAAKLKKLVSQILLEAIRIDRDMGMYMFDMYNKGWLSVAGGEGKVPQFKSVEEYQAYRRDDFGIRAFWPMVEFGMAMRLSDEDKKLIEPVMEPIDKAIIWTNDYWSFDREYHESITNGSRLTNVVEVVRQIENKSIDEAKAAVRQLLVNLEQQYLERKRAIYAQNPSIPSHLRKWIEVVGITVAGTHFWASCSPRHHAWRNNSRNGLKPANHVAAPTLITPSNNLNSSKGSEEQMQDSDNGTRTQMCPANDHEVMQLNAKLSLGKQDGGHAMRAALALLSRAAEQCESLFDGMEHERARLLQSGEEKARLSWEGRSKGSQELEHSWYKPAKTALQAPIHYICSMPSKGVRSRMIEAFNYWLEVDETSLTKIRRLVDLLHNASLILDDIEDHSPKRRGRPATHTIFGHSQAINSANFMFVQAVQVARQFRNPNAVDILLEELENLYLGQSWDLDWKYKLRCPSPSEYLNMVDNKTGGLFRLLLRLMQAERKGTTEVDLDGLTVLFGRFFQIRDDYMNLRSGLYTEQKGFCEDLDEGKFSYPIVVCVANHADFRDLIDGVFRQRPTAITSGMQPLAPEIKRYVVEYLNTSGTFQHCREFLMQLESLIESEIDRIEKVTNEANPMLRLLLEKLSVKEN",
        "proteome": "UP000006702",
        "gene": "NfSS",
        "go_terms": [
            {
                "identifier": "GO:0004659",
                "name": "prenyltransferase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0008299",
                "name": "isoprenoid biosynthetic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 1,
        "source_database": "reviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "c4d4b18be30759cab5994beb2eef2bfa097a743b",
        "counters": {
            "domain_architectures": 992,
            "entries": 11,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 1,
            "structures": 1,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "ssf": 1,
                "pfam": 2,
                "panther": 1,
                "sfld": 1,
                "prosite": 2,
                "interpro": 3
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 992
        }
    }
}