{"metadata":{"accession":"A1DN30","id":"NFSS_NEOFI","source_organism":{"taxId":"331117","scientificName":"Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)","fullName":"Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)"},"name":"Sesterfisherol synthase","description":["Bifunctional terpene synthase; part of the gene cluster that mediates the biosynthesis of sesterfisheric acid (PubMed:26332841). The bifunctional terpene synthase NfSS converts dimethylallyl diphosphate (DMAPP) and isopentenyl diphosphate (IPP) into sesterfisherol (PubMed:26332841, PubMed:29410538). The C-terminal prenyltransferase (PT) domain of NfSS catalyzes formation of geranylfarnesyl pyrophosphate (GFPP), whereas the N-terminal terpene cyclase (TC) domain catalyzes the cyclization of GFPP to sesterfisherol (PubMed:26332841, PubMed:29410538). The cytochrome P450 monooxygenase NfP450 then catalyzes oxidative modifications of sesterfisherol into sesterfisheric acid (PubMed:26332841)"],"length":764,"sequence":"MEVWEHSRPIADDTIKKTPSFTTLPIRINKQNDVADAATRRALRDWDYYLHDGLAERALISISELGNLGAFAYPEVPPERLAIVTYLTDLGILHDDGYEAMDMDQARTEHREFGALFDPHEQLPSRRGTRAAKLKKLVSQILLEAIRIDRDMGMYMFDMYNKGWLSVAGGEGKVPQFKSVEEYQAYRRDDFGIRAFWPMVEFGMAMRLSDEDKKLIEPVMEPIDKAIIWTNDYWSFDREYHESITNGSRLTNVVEVVRQIENKSIDEAKAAVRQLLVNLEQQYLERKRAIYAQNPSIPSHLRKWIEVVGITVAGTHFWASCSPRHHAWRNNSRNGLKPANHVAAPTLITPSNNLNSSKGSEEQMQDSDNGTRTQMCPANDHEVMQLNAKLSLGKQDGGHAMRAALALLSRAAEQCESLFDGMEHERARLLQSGEEKARLSWEGRSKGSQELEHSWYKPAKTALQAPIHYICSMPSKGVRSRMIEAFNYWLEVDETSLTKIRRLVDLLHNASLILDDIEDHSPKRRGRPATHTIFGHSQAINSANFMFVQAVQVARQFRNPNAVDILLEELENLYLGQSWDLDWKYKLRCPSPSEYLNMVDNKTGGLFRLLLRLMQAERKGTTEVDLDGLTVLFGRFFQIRDDYMNLRSGLYTEQKGFCEDLDEGKFSYPIVVCVANHADFRDLIDGVFRQRPTAITSGMQPLAPEIKRYVVEYLNTSGTFQHCREFLMQLESLIESEIDRIEKVTNEANPMLRLLLEKLSVKEN","proteome":"UP000006702","gene":"NfSS","go_terms":[{"identifier":"GO:0004659","name":"prenyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008299","name":"isoprenoid biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"c4d4b18be30759cab5994beb2eef2bfa097a743b","counters":{"domain_architectures":992,"entries":11,"isoforms":0,"proteomes":1,"sets":1,"structures":1,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":2,"panther":1,"sfld":1,"prosite":2,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":992}}}