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{
    "metadata": {
        "accession": "A0AAN8AI67",
        "id": "A0AAN8AI67_ELEMC",
        "source_organism": {
            "taxId": "56733",
            "scientificName": "Eleginops maclovinus",
            "fullName": "Eleginops maclovinus (Patagonian blennie)"
        },
        "name": "Activin receptor type-1C",
        "description": [
            "Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells. Acts as a positive regulator for macrophage activation partially through down-regulation of PPARG expression"
        ],
        "length": 497,
        "sequence": "MAIREVALTLLALCGFVAVGDALRCNCTNCEKTGFECETDGACMASTYYIQEKKQHVRICINRDNLVPPGQPFYCLSAEGLLNTHCCYSDYCNSIEVPVPTKEGDWSASGGSWGPVELVAVIAGPVFLLCVLLMVGVFLFQYHQRAYSHRQRLEVEDPSCDHLYMAKDKTLQDLIYDMSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGKWRGGDVAVKIFSSREERSWFREAEIYQTIMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYSVTIEGMIKLALSAASGLAHLHMEILGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHESITDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNAGGIHEEYQLPYYDLVPSDPSIEEMRKLVCDQKLRPNVPNWWQSYESLRVMGKIMRECWYANGAARLTALRIKKTLSQLSVEEDVKM",
        "proteome": "UP001346869",
        "gene": "PBY51_000584",
        "go_terms": [
            {
                "identifier": "GO:0004675",
                "name": "transmembrane receptor protein serine/threonine kinase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0005524",
                "name": "ATP binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006468",
                "name": "protein phosphorylation",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0004672",
                "name": "protein kinase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0007178",
                "name": "cell surface receptor protein serine/threonine kinase signaling pathway",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "52bbca3e8c17a0ff34c2954755349db89b8cc820",
        "counters": {
            "domain_architectures": 2665,
            "entries": 25,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 3,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 2,
                "cdd": 2,
                "cathgene3d": 3,
                "pfam": 3,
                "profile": 2,
                "smart": 2,
                "panther": 1,
                "prosite": 2,
                "interpro": 8
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 2665
        }
    }
}