{"metadata":{"accession":"A0AAN8AI67","id":"A0AAN8AI67_ELEMC","source_organism":{"taxId":"56733","scientificName":"Eleginops maclovinus","fullName":"Eleginops maclovinus (Patagonian blennie)"},"name":"Activin receptor type-1C","description":["Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells. Acts as a positive regulator for macrophage activation partially through down-regulation of PPARG expression"],"length":497,"sequence":"MAIREVALTLLALCGFVAVGDALRCNCTNCEKTGFECETDGACMASTYYIQEKKQHVRICINRDNLVPPGQPFYCLSAEGLLNTHCCYSDYCNSIEVPVPTKEGDWSASGGSWGPVELVAVIAGPVFLLCVLLMVGVFLFQYHQRAYSHRQRLEVEDPSCDHLYMAKDKTLQDLIYDMSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGKWRGGDVAVKIFSSREERSWFREAEIYQTIMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYSVTIEGMIKLALSAASGLAHLHMEILGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHESITDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNAGGIHEEYQLPYYDLVPSDPSIEEMRKLVCDQKLRPNVPNWWQSYESLRVMGKIMRECWYANGAARLTALRIKKTLSQLSVEEDVKM","proteome":"UP001346869","gene":"PBY51_000584","go_terms":[{"identifier":"GO:0004675","name":"transmembrane receptor protein serine/threonine kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004672","name":"protein kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007178","name":"cell surface receptor protein serine/threonine kinase signaling pathway","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"52bbca3e8c17a0ff34c2954755349db89b8cc820","counters":{"domain_architectures":2665,"entries":25,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"cdd":2,"cathgene3d":3,"pfam":3,"profile":2,"smart":2,"panther":1,"prosite":2,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":2665}}}