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{
    "metadata": {
        "accession": "A0AAA9S721",
        "id": "A0AAA9S721_BOVIN",
        "source_organism": {
            "taxId": "9913",
            "scientificName": "Bos taurus",
            "fullName": "Bos taurus (Bovine)"
        },
        "name": "E3 ubiquitin-protein ligase MARCHF7",
        "description": [
            "E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in T-cell proliferation by regulating LIF secretion. May play a role in lysosome homeostasis. Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7. Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation"
        ],
        "length": 637,
        "sequence": "MESKPSRIPRRISVQPASSLSARLMSGSRGSGLNDTYHSRDSSFRLDSEYQSASAAASPFQPTWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTSTSTGRSVGHGLNAVSGVQDRVPSSYSQGARPKENSLSTLQLSASSTNHQMPSEHQTIPCSRDSGRNSLRSNFSPRELESPQSSMQPGFSYTSNRGETSTIGSSDRINSSHRSFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSNQDSLNTRSLSSENSYVSPRILTGSQSRGNAASASDIPDNRASEASQGFRFLRRRWGLSSLSQNHNSEPDSQNFSQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRISTSDIPSRSHHLFRRESNEVVHLEAQSEPLGAGANRPQASAAPSSVGTGDSPSDSTRSGRSTGITGILPGSLFRFAVPPALGNNLTDNVMITVDIIPSGWSSSDGKNDKTKNVPSRDPERLQKIKESLLLEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQECMKKWLQAKINSGSSLEAVTTCELCKEKLQLNLEDFDIHELHRARANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTNEPSTRVRLQKMILKRMETITEHLILPNCI",
        "proteome": "UP000009136",
        "gene": "MARCHF7",
        "go_terms": [
            {
                "identifier": "GO:0008270",
                "name": "zinc ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "8bf2bfef483bdf06a92e8e46fc0070a14fb9f871",
        "counters": {
            "domain_architectures": 28235,
            "entries": 10,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "profile": 1,
                "ssf": 1,
                "smart": 1,
                "pfam": 1,
                "cdd": 1,
                "panther": 1,
                "interpro": 3
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 28235
        }
    }
}