{"metadata":{"accession":"A0AAA9S721","id":"A0AAA9S721_BOVIN","source_organism":{"taxId":"9913","scientificName":"Bos taurus","fullName":"Bos taurus (Bovine)"},"name":"E3 ubiquitin-protein ligase MARCHF7","description":["E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in T-cell proliferation by regulating LIF secretion. May play a role in lysosome homeostasis. Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7. Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation"],"length":637,"sequence":"MESKPSRIPRRISVQPASSLSARLMSGSRGSGLNDTYHSRDSSFRLDSEYQSASAAASPFQPTWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTSTSTGRSVGHGLNAVSGVQDRVPSSYSQGARPKENSLSTLQLSASSTNHQMPSEHQTIPCSRDSGRNSLRSNFSPRELESPQSSMQPGFSYTSNRGETSTIGSSDRINSSHRSFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSNQDSLNTRSLSSENSYVSPRILTGSQSRGNAASASDIPDNRASEASQGFRFLRRRWGLSSLSQNHNSEPDSQNFSQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRISTSDIPSRSHHLFRRESNEVVHLEAQSEPLGAGANRPQASAAPSSVGTGDSPSDSTRSGRSTGITGILPGSLFRFAVPPALGNNLTDNVMITVDIIPSGWSSSDGKNDKTKNVPSRDPERLQKIKESLLLEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQECMKKWLQAKINSGSSLEAVTTCELCKEKLQLNLEDFDIHELHRARANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTNEPSTRVRLQKMILKRMETITEHLILPNCI","proteome":"UP000009136","gene":"MARCHF7","go_terms":[{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"8bf2bfef483bdf06a92e8e46fc0070a14fb9f871","counters":{"domain_architectures":28235,"entries":10,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"profile":1,"ssf":1,"smart":1,"pfam":1,"cdd":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":28235}}}