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{
    "metadata": {
        "accession": "A0A8X6EH27",
        "id": "CAPW_STEMA",
        "source_organism": {
            "taxId": "40324",
            "scientificName": "Stenotrophomonas maltophilia",
            "fullName": "Stenotrophomonas maltophilia (Pseudomonas maltophilia)"
        },
        "name": "DNA-binding transcriptional repressor CapW",
        "description": [
            "Transcriptional regulator of a CBASS antivirus system (Probable). CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage (PubMed:35536256). The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals (PubMed:35536256). The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection (PubMed:35536256). A type III CBASS system, part of a CapW-Cap6-Cap8-Cap7-CdnC-NucC locus (PubMed:35536256). Binds specifically to palindromes that overlap the -10 site in the promoter of cap6, found beween found between the genes for divergently transcribed capW and cap6 (cognate DNA) (PubMed:35536256). Probably represses transcription bidirectionally from the promoter (PubMed:35536256). Mutations that make it a constitutive repressor in E.coli do not change DNA-binding affinity (Probable) (PubMed:35536256)"
        ],
        "length": 299,
        "sequence": "MESSGSSKVRWGQNRRLNFIDVRLQYDGRINRSDLMQFFDISAPQASADLGLYQQLAGDNLVYDTRQRIYLATPEFKPITKRSEATRYLNELQRLARGIVEPDESFVGYQPSTGVVVSPSRAIEADEVATLLRAIRDRVALRVRYQSMDAPEPQEWVLSPHALGFDGLRWHARAWCHARQVFRDFAIGRLDVLEHVFSAKPVDPLLDEGWNNEVTVSLVPHPGLTPSQRRVVMRDYGMVDGHCELRCRKAMLFYTLRHLNLESLAISDVPAQQHVVVENAEEVKQWMREDRDGLQHLRR",
        "proteome": null,
        "gene": "capW",
        "go_terms": null,
        "protein_evidence": 1,
        "source_database": "reviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "fab87996018e212a64e3d18228e563efe364c1a5",
        "counters": {
            "domain_architectures": 2772,
            "entries": 11,
            "isoforms": 0,
            "proteomes": 0,
            "sets": 2,
            "structures": 1,
            "taxa": 1,
            "dbEntries": {
                "pfam": 3,
                "profile": 1,
                "pirsf": 1,
                "panther": 1,
                "interpro": 5
            },
            "proteome": 0,
            "taxonomy": 1,
            "similar_proteins": 2772
        }
    }
}