{"metadata":{"accession":"A0A8X6EH27","id":"CAPW_STEMA","source_organism":{"taxId":"40324","scientificName":"Stenotrophomonas maltophilia","fullName":"Stenotrophomonas maltophilia (Pseudomonas maltophilia)"},"name":"DNA-binding transcriptional repressor CapW","description":["Transcriptional regulator of a CBASS antivirus system (Probable). CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage (PubMed:35536256). The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals (PubMed:35536256). The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection (PubMed:35536256). A type III CBASS system, part of a CapW-Cap6-Cap8-Cap7-CdnC-NucC locus (PubMed:35536256). Binds specifically to palindromes that overlap the -10 site in the promoter of cap6, found beween found between the genes for divergently transcribed capW and cap6 (cognate DNA) (PubMed:35536256). Probably represses transcription bidirectionally from the promoter (PubMed:35536256). Mutations that make it a constitutive repressor in E.coli do not change DNA-binding affinity (Probable) (PubMed:35536256)"],"length":299,"sequence":"MESSGSSKVRWGQNRRLNFIDVRLQYDGRINRSDLMQFFDISAPQASADLGLYQQLAGDNLVYDTRQRIYLATPEFKPITKRSEATRYLNELQRLARGIVEPDESFVGYQPSTGVVVSPSRAIEADEVATLLRAIRDRVALRVRYQSMDAPEPQEWVLSPHALGFDGLRWHARAWCHARQVFRDFAIGRLDVLEHVFSAKPVDPLLDEGWNNEVTVSLVPHPGLTPSQRRVVMRDYGMVDGHCELRCRKAMLFYTLRHLNLESLAISDVPAQQHVVVENAEEVKQWMREDRDGLQHLRR","proteome":null,"gene":"capW","go_terms":null,"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"fab87996018e212a64e3d18228e563efe364c1a5","counters":{"domain_architectures":1876,"entries":11,"isoforms":0,"proteomes":0,"sets":2,"structures":1,"taxa":1,"dbEntries":{"pfam":3,"profile":1,"pirsf":1,"panther":1,"interpro":5},"proteome":0,"taxonomy":1,"similar_proteins":1876}}}