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{
    "metadata": {
        "accession": "A0A8M1M3L7",
        "id": "A0A8M1M3L7_NEOSC",
        "source_organism": {
            "taxId": "29088",
            "scientificName": "Neomonachus schauinslandi",
            "fullName": "Neomonachus schauinslandi (Hawaiian monk seal)"
        },
        "name": "Interleukin-3 receptor subunit alpha",
        "description": [
            "Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program"
        ],
        "length": 489,
        "sequence": "MALVWLTVFLTSVSGLLQSEEDPNLPIKNLRMEPAERRLTWDLHGNVPEILCFINSKRITKAIDNNHYCQFQVLPLCEVKNFTISLTKGPPFLMGIQYPLQEGNPGAAAQRLDCWVHDVDFLTCSWEVGREAPGDVQYRLYWQELRTHREQECPHYETDDRGKHVRCHFNDVSRLPKHLQILVRGTSHGASIPCVDRSVELSEIDFAHSLTLEGPFPLLPITLNFYEACFQSIFWEWAGGMLICFTHKSLFVFFFPPVLERLSSPNITATCNKSYSMMEWKVLSHVNHRFEYELQIQKGSNPAYTEKLQENFFQIHNPGNYMARLKVKGFFRNTWSEWSVPQYFGPRGPRGEPEVFADRGPVPSWTRPSACCLSGSPWGRLQGWVQAPALGPADVPRPPSSVVCDLGEDSRWPDWLLTALVLLGTLLVPGLAVVLCGRYSVLQKLFPPIPHMKDPITDNLQSSKLVAWEASRASREDCPVAEVQVLGET",
        "proteome": "UP000248481",
        "gene": "IL3RA",
        "go_terms": [
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0004896",
                "name": "cytokine receptor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "fc8a0326fe8f047c07936d6280c27651a630b72e",
        "counters": {
            "domain_architectures": 748,
            "entries": 12,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "pfam": 2,
                "ssf": 1,
                "panther": 1,
                "prosite": 1,
                "interpro": 5
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 748
        }
    }
}