{"metadata":{"accession":"A0A8M1M3L7","id":"A0A8M1M3L7_NEOSC","source_organism":{"taxId":"29088","scientificName":"Neomonachus schauinslandi","fullName":"Neomonachus schauinslandi (Hawaiian monk seal)"},"name":"Interleukin-3 receptor subunit alpha","description":["Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program"],"length":489,"sequence":"MALVWLTVFLTSVSGLLQSEEDPNLPIKNLRMEPAERRLTWDLHGNVPEILCFINSKRITKAIDNNHYCQFQVLPLCEVKNFTISLTKGPPFLMGIQYPLQEGNPGAAAQRLDCWVHDVDFLTCSWEVGREAPGDVQYRLYWQELRTHREQECPHYETDDRGKHVRCHFNDVSRLPKHLQILVRGTSHGASIPCVDRSVELSEIDFAHSLTLEGPFPLLPITLNFYEACFQSIFWEWAGGMLICFTHKSLFVFFFPPVLERLSSPNITATCNKSYSMMEWKVLSHVNHRFEYELQIQKGSNPAYTEKLQENFFQIHNPGNYMARLKVKGFFRNTWSEWSVPQYFGPRGPRGEPEVFADRGPVPSWTRPSACCLSGSPWGRLQGWVQAPALGPADVPRPPSSVVCDLGEDSRWPDWLLTALVLLGTLLVPGLAVVLCGRYSVLQKLFPPIPHMKDPITDNLQSSKLVAWEASRASREDCPVAEVQVLGET","proteome":"UP000248481","gene":"IL3RA","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004896","name":"cytokine receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"fc8a0326fe8f047c07936d6280c27651a630b72e","counters":{"domain_architectures":748,"entries":12,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"pfam":2,"ssf":1,"panther":1,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":748}}}