General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "A0A8J1JR51",
        "id": "A0A8J1JR51_XENTR",
        "source_organism": {
            "taxId": "8364",
            "scientificName": "Xenopus tropicalis",
            "fullName": "Xenopus tropicalis (Western clawed frog)"
        },
        "name": "Histone-lysine N-methyltransferase 2C",
        "description": [
            "Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements"
        ],
        "length": 5103,
        "sequence": "MSAGPFPRMSSEDKSLESACEQPGPQGPASPAATDKRPRGRPRKDGSSPLQRARKKPRSRGKAALEDEDSMDGLEGAEPENSADTDIKEQPVEEGAASDAAGIAQLTPALQHSLLEESERSTASVGVQAKTSEQLCAFCYCGERSLLGQGELKLFRPTPGFPLPWKTHSETTDTESNDETCKNSGRTEKQRGPRKAKSPQNGGACANASTQTSSDEPAGKFWDELCQVGLLDDFHIQALFEPSGHCWAHLRCAQWSPGVHQNEEQELVSVDKAVLSGSTERCAYCKHLGATIKCCEETCTQTYHYPCAAGAGTFQDLNCLTLLCPEHIDQALERSKEDANCALCDSSGDLLDQLFCTTCGQHYHGMCLDIAVTPLKRAGWQCPDCKVCQNCKHSGDDNQMLVCDTCDKGYHTFCLQPVMDSVPTNGWKCKNCRICTECGTRTSSLWHLNCLLCDPCFQQQVSLPCPICDKPLQPELQKDMLHCHVCKRWIHLDCEKCTENDIDDQLKEDYACTLCKQLAEEAEPGDHCVGMEVTESNNVCTGEMEMDTGRKTTFQDKALNHNNIAPDSTTVCITEETPLHNEKAKLENDFSHSDDPEEMETSHAEIENPMPEGVKEKAERERHLLLPQSVSRHDGPKSVLPPETEASVKDKTASKTLEVSHKSPMSESKVESCSKMAEHFDSTGGHEGTAQENNDPLVPETPHVGEMEATPTSESLTEAGSPFVDKALKSPAGMDSPVTSVDTSKTSVSSSPAVSIDFHPSHDLYQSQTPVTSHSTGNAFPTTFISVTPKIGMGKPAITKRKFSPGRPRSRQGAWSSHNTVSPPSWSPDGSEGWDILKSRQLLGNPYWSIKVGRGSGFPKRRPRGSGLSGRGGRGRAKLKAPINNFIFPGITTFDVSSYKEEEETSMHNTVVLFSRSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKVILRKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTFCLDPPLQTVPKGGWKCKWCVSCTNCKAITPGLRCEWQNNYTQCAPCASLSACPVCCQNYIEEELILQCRQCIRWSHASCQNLNTEAEVELAADSGFDCAACKPFVVSHEVIEPTIDAQIIPKTRDSDVLKTFTQDGVCLTESGLSQLQSLTITVQRKKRSKPKLKLKIINQNSVAVLQTPPYPQSEHSRDGEMDDSREVDLMDCDVKSDSSPEREPIDDDSKSTEVMDGLKKRKRKPYRPGIGGFMVRQRSRTGQGKSRRSLSRKDSSGSVSELLPGKDESWSEQLPETPLEDCIPGSDGTEKIKKRYRKKKNKLEETFPAYLQEAFFGRNLLDTSRQSKASTENLTEDTSHILYRANVNTSFLDPSSDPMLSSAATFTPSKQSEGSTRDPLADLSEVLNTEDDIFGILTDDTNPTGMSTKGLDLCTFQVENSPSPFAGLDIGTMSDDSSALTQSSVAQTSRPLSEDQLDGILSPELDKMVTDGAILGKMYKIPELEGKDVEDLFTAVLSPLATHPPSLPQPPPPSAHPHPPHTQLLPLHNQGNGFFPRMPMVNGLMPPNSHLQHNPLAPGAGLGTFSPLAHPPYAESREKAPLFRSMGNEPAGSWPTQAQSLESEGDTMSNAQRSTLKWEKEEALGEMATVAPVLYTNVNFPNLKDEFPDWATRVKQIAKLWRKASSQERAPYVQKARDNRAALRINKVQMSNDSLKRQQHEILEHSRIESDLFKDPLKQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQVKSEQQQQQQQQFGSQQHLSQSGSDTPNSGIQSPLTPQPGSENMSPVQQGFNKDIFSKQPMPGTPTSFSDDVFLKPQAPPPTPTRIPLQDSYQFSQSSQPPSPQMFSPGSSNSRPTSPVDPYAKMVGTPRPPPTGQTFHRRNSRSPVDVCPSRTSSGCEMNDNRPSPVRDSCSSPVGSDPSLKIPHSQRSLMSSESLSKLTGVGRLPVNADQALEGSLMLGSNDSFARLPSRSDVFQRQQMAHSKVVDQYKRPPLAPTPGIADGSSAPFKTPMRPPQSPQESYGLSITSRRLSADPYERPPLTPRPAENFSHDPYSQSALSSHPALNEPFVHPHRVVRLHNDTISRTNTQDPYAQQPGTPRPVSNPFLQSPRSAVIDHYIQQPSRPPVQPADPYSQPPGTPRPNMGDMFVPPTMSKRHHDPFSPGNSRQVVDPYSQQPGTPRPVSVDPYSQPPGTPRPVPSDPYAKPPGTPRPVPSDPYSQPPGTPRPVPSDPYSQPPGTPRPVPSDPYSQPPGTPRPIPSDPYSQPPGTPRPIPSDPYSQPPGTPRPIPSDPYSQPPGTPRPVPSDPYSQPPGTPRPVPSDPYSQPPGTPRPVPSDPYSQPPGTPRPVTSDPYSQPPGTPRPVASDPYSQPPGTPRPVLSDPYSQPPRTPRPVLCDPYAQPPRTPMPGILENCSPAIRGGLLPNQEHFRQTAHLRGPSMLVPFVRPSDQNPRPAGPGPSDMFGHSSAGLSHDPYDQPPMTPRMQAVDGFGDATEVVDPQRPIIEEAFVAPAGINANPQVQPFPSMQQGLAVISDAQNSLTLTQAESEEKLRQRQKLRELILRQQQSKHSVRQEKALLDPLQIPQGGHPTHWQPENPPPVQSEVFNRPPPPYPGSIRVSFGPKGSPRFPVFPKDQRGPFPGNGQFNRPPFSGDMSSMRMRPPQGNRMAYPMVGPGSVLGHERFVGNPLQMQMTGMQPQMRRDMSIELTRPVGSTQMSNSVGLPLHFPHQGMQQHSISGQAYIELRHRPPDGRPRILFAPPNLMDGSQNIRHGGFFPRSDCHGQRLMDPSRVPHPDLPNPMQIPPDLDQLIPATPQGHLLPSDHQPVLVMGGMEPPSGTETFLQSSLPPMNSHEEADNLPIDGQTNSGLEVKLDPDDPSVKDLDVKDLVGVEVKDLDDDDLDNINLDDAKGDELDALDNLETNDPQLDDLLKSGKFDIIAYTDPELDLGDKKDLFNEDLDLGVPIDDKLDLPSKSDDITTEQHGSQATSTTLLSVPQASGVSLESKGDLMSSNSSDRPSVEVKSELGVEARTQQHDENSASVPLCSTECSVKREKEAHPSAHISEDAIALPEQDIGSSGNLPESTPVLAGLLSSDKSGNAEVESLDCAPGAVVATEPCIPQDVRTSEQLMEQALNPSMTPRLNHGFPQGSPSKSPFVSALPSGHNFVSGENPSQTIPLPNQPCAAGLPSAQQLMLQQSRERPLLLEEQPLLLQDLLDQERQEQQQQRQMQAMIRQRSEPFFPNIDFDAITDPIMKAKMVALKGINKVMAQNNLGIPPMVINRFPFMAQQMSSAQAPDSQSIVQQAITQDGSLAPQMTRPNPPSFGPGFVNDSQKKKYEDWLQETQQLLQIQQKFLEEQIGAHRKSKKALSAKQRAAKKTGREFPEEDAEQLKQVTEQQSMVQKQLEQIRKQQKEHTELIEEYRTKQHQQFSITPMIPGGQHQQPVMPGGAPTSVNPQNFPLAQTLHPQAPVILGQANPSRMPSLPGWQAPNAPRALVQPNAPRAQRPTNADVANSNPNAPPRVEFDDNNPFSETFQERERKERLREQQERQRIQLMQEVDRQRVLQQRLEMEQHGMIGPDLNNGSLSQMPFFSSELPSDFMQLPQPSQQPPQASHTMPQQNLQQGLVNSPPAANFIQTAERSPMGLSPFGQGAQPVQSVQQSPGSILSTGHAKPPFASSVPSASPAADNGHSSEQDNSNTSSHQAPSQSLIQLYSAIIPEEKGKKKRQRKKKKDDETESVKSPSTPRSDMTAPLTPSLSEASTPTVTAPNDLAYQAEHPNDFIRSSTPNVTGNTAVELEDPLVPADVKQRLFQEPNPERTAAGQHHTTEALKIQNIKLERADEDQAVEAAQEEGKMEENKATSHNALSMDITSQPASGPSGKLESGNELLKHLLKNKKDPFMLHQKSEESLRSEEHCPLNVKVPEMQGHLNSLQMPENKEPGCFNLNQSLFQKSEFEMEKKKPRNKRVQRSEGKATPRSKKRKKDEEQKSAIYANAETFTQIKQQLSLLPLIEPIVGMNIAQFLPYGAGSVCTGSRLHGTFGSASLEGVSDYYSQLIFKQNNLSNPPTPPASLPPTPPPVSCQKLVNGFATTEELAGKAAILGGHVTKALGPKQFQLPFRTQDDLIARAMTQGPKSVDVPASLPTPPHNNQEELRAQDHCDSRDSPDSFVPSSSPESVVGIEIRRYPDLSLVKEEPPDPAQSPIIPILPSSMGKGSVLRDCAFKTEPPPGTMFFGPQFVQAPSGPKTGLISVAITLHPTAAENISGVVAAFADLLQVQIPTSYEVSNAREPGSVILMNGHRLNPNMDYRQQFFRQRPRPGPLPPGRLIGPYGLRPQNLPFLSSDNGFRHNNSNIESSPVLKPSWCCHCKVVVLGCGVRKSMKDLSFFKQECLRSPGRMDGNLVFCSNNCFLLYSAAQSKHLEAKRPDPSFLPPSVKEAQPKSCHQYNTNTSTLDVHCLPLLQEKSSPPTSPPISFPPAAFQTAKVEAKPDELKVTVKLKPRPRAVHGGYDDCRPASKKWRGMKWKKWSVQIVIPKMPFKPQCENELAEMFRRLGTSLKPHPLCKDYRKCCFCHEEGDGLTDGSARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCGFCHKTGATSSCHRLRCTNIYHFTCAIKAQCMFFKDKTMLCTMHKPKGLHEQELTYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHAIGQLLPQQMQNFHSATALFPVGFEASRLYWSMRYANRRCRYLCSIEENDGLPLFVVRVIEPGHEELVLMDSSLKGVWDKILEPVANCRKGSEILRLFPVFLKGEDLYGLTASAVTRIAESLPGVEACENYTFRYGRNPLMELPLAINPSGSARSEPKMNSHVKRFVLRPHTLNSTSTSKSFQSTVTGELNAPYSKQFVHSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRIDNEHVIDATLTGGPARYINHSCAPNCVAEVVTFEKGHRIIISSNRRIQKGEELSYDYKFDFEDDQHKIPCHCGAVNCRKWMN",
        "proteome": "UP000008143",
        "gene": "kmt2c",
        "go_terms": [
            {
                "identifier": "GO:0042800",
                "name": "histone H3K4 methyltransferase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0044666",
                "name": "MLL3/4 complex",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0005634",
                "name": "nucleus",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006355",
                "name": "regulation of DNA-templated transcription",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": false,
        "in_bfvd": false,
        "ida_accession": "5bda398aba0763c87ec8139d84177767c0d96f3d",
        "counters": {
            "domain_architectures": 1551,
            "entries": 50,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 5,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "profile": 6,
                "cathgene3d": 4,
                "pfam": 6,
                "smart": 6,
                "ssf": 3,
                "cdd": 7,
                "panther": 1,
                "prosite": 1,
                "interpro": 16
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 1551
        }
    }
}