{"metadata":{"accession":"A0A8J1JR51","id":"A0A8J1JR51_XENTR","source_organism":{"taxId":"8364","scientificName":"Xenopus tropicalis","fullName":"Xenopus tropicalis (Western clawed frog)"},"name":"Histone-lysine N-methyltransferase 2C","description":["Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements"],"length":5103,"sequence":"MSAGPFPRMSSEDKSLESACEQPGPQGPASPAATDKRPRGRPRKDGSSPLQRARKKPRSRGKAALEDEDSMDGLEGAEPENSADTDIKEQPVEEGAASDAAGIAQLTPALQHSLLEESERSTASVGVQAKTSEQLCAFCYCGERSLLGQGELKLFRPTPGFPLPWKTHSETTDTESNDETCKNSGRTEKQRGPRKAKSPQNGGACANASTQTSSDEPAGKFWDELCQVGLLDDFHIQALFEPSGHCWAHLRCAQWSPGVHQNEEQELVSVDKAVLSGSTERCAYCKHLGATIKCCEETCTQTYHYPCAAGAGTFQDLNCLTLLCPEHIDQALERSKEDANCALCDSSGDLLDQLFCTTCGQHYHGMCLDIAVTPLKRAGWQCPDCKVCQNCKHSGDDNQMLVCDTCDKGYHTFCLQPVMDSVPTNGWKCKNCRICTECGTRTSSLWHLNCLLCDPCFQQQVSLPCPICDKPLQPELQKDMLHCHVCKRWIHLDCEKCTENDIDDQLKEDYACTLCKQLAEEAEPGDHCVGMEVTESNNVCTGEMEMDTGRKTTFQDKALNHNNIAPDSTTVCITEETPLHNEKAKLENDFSHSDDPEEMETSHAEIENPMPEGVKEKAERERHLLLPQSVSRHDGPKSVLPPETEASVKDKTASKTLEVSHKSPMSESKVESCSKMAEHFDSTGGHEGTAQENNDPLVPETPHVGEMEATPTSESLTEAGSPFVDKALKSPAGMDSPVTSVDTSKTSVSSSPAVSIDFHPSHDLYQSQTPVTSHSTGNAFPTTFISVTPKIGMGKPAITKRKFSPGRPRSRQGAWSSHNTVSPPSWSPDGSEGWDILKSRQLLGNPYWSIKVGRGSGFPKRRPRGSGLSGRGGRGRAKLKAPINNFIFPGITTFDVSSYKEEEETSMHNTVVLFSRSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKVILRKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTFCLDPPLQTVPKGGWKCKWCVSCTNCKAITPGLRCEWQNNYTQCAPCASLSACPVCCQNYIEEELILQCRQCIRWSHASCQNLNTEAEVELAADSGFDCAACKPFVVSHEVIEPTIDAQIIPKTRDSDVLKTFTQDGVCLTESGLSQLQSLTITVQRKKRSKPKLKLKIINQNSVAVLQTPPYPQSEHSRDGEMDDSREVDLMDCDVKSDSSPEREPIDDDSKSTEVMDGLKKRKRKPYRPGIGGFMVRQRSRTGQGKSRRSLSRKDSSGSVSELLPGKDESWSEQLPETPLEDCIPGSDGTEKIKKRYRKKKNKLEETFPAYLQEAFFGRNLLDTSRQSKASTENLTEDTSHILYRANVNTSFLDPSSDPMLSSAATFTPSKQSEGSTRDPLADLSEVLNTEDDIFGILTDDTNPTGMSTKGLDLCTFQVENSPSPFAGLDIGTMSDDSSALTQSSVAQTSRPLSEDQLDGILSPELDKMVTDGAILGKMYKIPELEGKDVEDLFTAVLSPLATHPPSLPQPPPPSAHPHPPHTQLLPLHNQGNGFFPRMPMVNGLMPPNSHLQHNPLAPGAGLGTFSPLAHPPYAESREKAPLFRSMGNEPAGSWPTQAQSLESEGDTMSNAQRSTLKWEKEEALGEMATVAPVLYTNVNFPNLKDEFPDWATRVKQIAKLWRKASSQERAPYVQKARDNRAALRINKVQMSNDSLKRQQHEILEHSRIESDLFKDPLKQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQVKSEQQQQQQQQFGSQQHLSQSGSDTPNSGIQSPLTPQPGSENMSPVQQGFNKDIFSKQPMPGTPTSFSDDVFLKPQAPPPTPTRIPLQDSYQFSQSSQPPSPQMFSPGSSNSRPTSPVDPYAKMVGTPRPPPTGQTFHRRNSRSPVDVCPSRTSSGCEMNDNRPSPVRDSCSSPVGSDPSLKIPHSQRSLMSSESLSKLTGVGRLPVNADQALEGSLMLGSNDSFARLPSRSDVFQRQQMAHSKVVDQYKRPPLAPTPGIADGSSAPFKTPMRPPQSPQESYGLSITSRRLSADPYERPPLTPRPAENFSHDPYSQSALSSHPALNEPFVHPHRVVRLHNDTISRTNTQDPYAQQPGTPRPVSNPFLQSPRSAVIDHYIQQPSRPPVQPADPYSQPPGTPRPNMGDMFVPPTMSKRHHDPFSPGNSRQVVDPYSQQPGTPRPVSVDPYSQPPGTPRPVPSDPYAKPPGTPRPVPSDPYSQPPGTPRPVPSDPYSQPPGTPRPVPSDPYSQPPGTPRPIPSDPYSQPPGTPRPIPSDPYSQPPGTPRPIPSDPYSQPPGTPRPVPSDPYSQPPGTPRPVPSDPYSQPPGTPRPVPSDPYSQPPGTPRPVTSDPYSQPPGTPRPVASDPYSQPPGTPRPVLSDPYSQPPRTPRPVLCDPYAQPPRTPMPGILENCSPAIRGGLLPNQEHFRQTAHLRGPSMLVPFVRPSDQNPRPAGPGPSDMFGHSSAGLSHDPYDQPPMTPRMQAVDGFGDATEVVDPQRPIIEEAFVAPAGINANPQVQPFPSMQQGLAVISDAQNSLTLTQAESEEKLRQRQKLRELILRQQQSKHSVRQEKALLDPLQIPQGGHPTHWQPENPPPVQSEVFNRPPPPYPGSIRVSFGPKGSPRFPVFPKDQRGPFPGNGQFNRPPFSGDMSSMRMRPPQGNRMAYPMVGPGSVLGHERFVGNPLQMQMTGMQPQMRRDMSIELTRPVGSTQMSNSVGLPLHFPHQGMQQHSISGQAYIELRHRPPDGRPRILFAPPNLMDGSQNIRHGGFFPRSDCHGQRLMDPSRVPHPDLPNPMQIPPDLDQLIPATPQGHLLPSDHQPVLVMGGMEPPSGTETFLQSSLPPMNSHEEADNLPIDGQTNSGLEVKLDPDDPSVKDLDVKDLVGVEVKDLDDDDLDNINLDDAKGDELDALDNLETNDPQLDDLLKSGKFDIIAYTDPELDLGDKKDLFNEDLDLGVPIDDKLDLPSKSDDITTEQHGSQATSTTLLSVPQASGVSLESKGDLMSSNSSDRPSVEVKSELGVEARTQQHDENSASVPLCSTECSVKREKEAHPSAHISEDAIALPEQDIGSSGNLPESTPVLAGLLSSDKSGNAEVESLDCAPGAVVATEPCIPQDVRTSEQLMEQALNPSMTPRLNHGFPQGSPSKSPFVSALPSGHNFVSGENPSQTIPLPNQPCAAGLPSAQQLMLQQSRERPLLLEEQPLLLQDLLDQERQEQQQQRQMQAMIRQRSEPFFPNIDFDAITDPIMKAKMVALKGINKVMAQNNLGIPPMVINRFPFMAQQMSSAQAPDSQSIVQQAITQDGSLAPQMTRPNPPSFGPGFVNDSQKKKYEDWLQETQQLLQIQQKFLEEQIGAHRKSKKALSAKQRAAKKTGREFPEEDAEQLKQVTEQQSMVQKQLEQIRKQQKEHTELIEEYRTKQHQQFSITPMIPGGQHQQPVMPGGAPTSVNPQNFPLAQTLHPQAPVILGQANPSRMPSLPGWQAPNAPRALVQPNAPRAQRPTNADVANSNPNAPPRVEFDDNNPFSETFQERERKERLREQQERQRIQLMQEVDRQRVLQQRLEMEQHGMIGPDLNNGSLSQMPFFSSELPSDFMQLPQPSQQPPQASHTMPQQNLQQGLVNSPPAANFIQTAERSPMGLSPFGQGAQPVQSVQQSPGSILSTGHAKPPFASSVPSASPAADNGHSSEQDNSNTSSHQAPSQSLIQLYSAIIPEEKGKKKRQRKKKKDDETESVKSPSTPRSDMTAPLTPSLSEASTPTVTAPNDLAYQAEHPNDFIRSSTPNVTGNTAVELEDPLVPADVKQRLFQEPNPERTAAGQHHTTEALKIQNIKLERADEDQAVEAAQEEGKMEENKATSHNALSMDITSQPASGPSGKLESGNELLKHLLKNKKDPFMLHQKSEESLRSEEHCPLNVKVPEMQGHLNSLQMPENKEPGCFNLNQSLFQKSEFEMEKKKPRNKRVQRSEGKATPRSKKRKKDEEQKSAIYANAETFTQIKQQLSLLPLIEPIVGMNIAQFLPYGAGSVCTGSRLHGTFGSASLEGVSDYYSQLIFKQNNLSNPPTPPASLPPTPPPVSCQKLVNGFATTEELAGKAAILGGHVTKALGPKQFQLPFRTQDDLIARAMTQGPKSVDVPASLPTPPHNNQEELRAQDHCDSRDSPDSFVPSSSPESVVGIEIRRYPDLSLVKEEPPDPAQSPIIPILPSSMGKGSVLRDCAFKTEPPPGTMFFGPQFVQAPSGPKTGLISVAITLHPTAAENISGVVAAFADLLQVQIPTSYEVSNAREPGSVILMNGHRLNPNMDYRQQFFRQRPRPGPLPPGRLIGPYGLRPQNLPFLSSDNGFRHNNSNIESSPVLKPSWCCHCKVVVLGCGVRKSMKDLSFFKQECLRSPGRMDGNLVFCSNNCFLLYSAAQSKHLEAKRPDPSFLPPSVKEAQPKSCHQYNTNTSTLDVHCLPLLQEKSSPPTSPPISFPPAAFQTAKVEAKPDELKVTVKLKPRPRAVHGGYDDCRPASKKWRGMKWKKWSVQIVIPKMPFKPQCENELAEMFRRLGTSLKPHPLCKDYRKCCFCHEEGDGLTDGSARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCGFCHKTGATSSCHRLRCTNIYHFTCAIKAQCMFFKDKTMLCTMHKPKGLHEQELTYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHAIGQLLPQQMQNFHSATALFPVGFEASRLYWSMRYANRRCRYLCSIEENDGLPLFVVRVIEPGHEELVLMDSSLKGVWDKILEPVANCRKGSEILRLFPVFLKGEDLYGLTASAVTRIAESLPGVEACENYTFRYGRNPLMELPLAINPSGSARSEPKMNSHVKRFVLRPHTLNSTSTSKSFQSTVTGELNAPYSKQFVHSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRIDNEHVIDATLTGGPARYINHSCAPNCVAEVVTFEKGHRIIISSNRRIQKGEELSYDYKFDFEDDQHKIPCHCGAVNCRKWMN","proteome":"UP000008143","gene":"kmt2c","go_terms":[{"identifier":"GO:0042800","name":"histone H3K4 methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0044666","name":"MLL3/4 complex","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"5bda398aba0763c87ec8139d84177767c0d96f3d","counters":{"domain_architectures":1551,"entries":50,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"profile":6,"cathgene3d":4,"pfam":6,"smart":6,"ssf":3,"cdd":7,"panther":1,"prosite":1,"interpro":16},"proteome":1,"taxonomy":1,"similar_proteins":1551}}}