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{
    "metadata": {
        "accession": "A0A8C4LMA2",
        "id": "A0A8C4LMA2_EQUAS",
        "source_organism": {
            "taxId": "9793",
            "scientificName": "Equus asinus",
            "fullName": "Equus asinus (Donkey)"
        },
        "name": "T-cell differentiation antigen CD6",
        "description": [
            "Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as a costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS"
        ],
        "length": 673,
        "sequence": "MAPDMWFFLVIAGWLMPTLAGDPSPTPSGLPNTSSAQSQTLEPGALLRVRLANGSSRCSGTVEVRLGAAWEPACGAPWDRRAAEAVCRALGCGRPGATVQPATLPPELTPGPAAGNASGAPNATQAPAPAVLCNGTEWRLCEVVEGACSSDARPAQVTCSENPELRLVDGGSPCAGRVEMLEDGQWGSVCDDTWDLEDAHVVCRQLSCGWAIQALPGLHFPPGQGPIHRDQVNCSGAESYLQDCPGQPGHGYCGHKEDAGVVCSEHQSWRLTGGTDSCEGQVEVHFRGVWNTVCDSEWYSEEATVLCRALGCGTAAARVPKGLPHSLSGRMYYSCEGTEPTLSDCFWRFNNSNLCRQSQAARVLCSGSRSLLNLSSSEAPTSVQPLTVESSVMMNTEDWESRELMLLILCIVLGVLLLGSFITIAFIFLKVKGKYALPVMANHEHLPTTTPAGINSYQDVPITISTKEVPNLPVQVQNPPPEDSDSSLDSDYEPYDFSAQPPVALTTFYNSQRHRPTDEEIQQSRFQMPPLEEGLEEMHASQVPPANPGHCIADAPSLGPQHHPRTKSGSSTSSGEGYCNNPSGRLPLWNPQAFSAEKTPFLEPPPNLELAGSQTTFSAGRSADDSSSTSSGEWYQNFQPPPQPPPEEQLEYPAPPSPQSESTSEDYDDIGAA",
        "proteome": "UP000694387",
        "gene": "CD6",
        "go_terms": [
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "ad5231f48af488f1e85b5e6e61a947e22a6b3e67",
        "counters": {
            "domain_architectures": 2801,
            "entries": 9,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 1,
                "cathgene3d": 1,
                "profile": 1,
                "smart": 1,
                "pfam": 1,
                "panther": 1,
                "prints": 1,
                "interpro": 2
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 2801
        }
    }
}