{"metadata":{"accession":"A0A8C4LMA2","id":"A0A8C4LMA2_EQUAS","source_organism":{"taxId":"9793","scientificName":"Equus asinus","fullName":"Equus asinus (Donkey)"},"name":"T-cell differentiation antigen CD6","description":["Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as a costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS"],"length":673,"sequence":"MAPDMWFFLVIAGWLMPTLAGDPSPTPSGLPNTSSAQSQTLEPGALLRVRLANGSSRCSGTVEVRLGAAWEPACGAPWDRRAAEAVCRALGCGRPGATVQPATLPPELTPGPAAGNASGAPNATQAPAPAVLCNGTEWRLCEVVEGACSSDARPAQVTCSENPELRLVDGGSPCAGRVEMLEDGQWGSVCDDTWDLEDAHVVCRQLSCGWAIQALPGLHFPPGQGPIHRDQVNCSGAESYLQDCPGQPGHGYCGHKEDAGVVCSEHQSWRLTGGTDSCEGQVEVHFRGVWNTVCDSEWYSEEATVLCRALGCGTAAARVPKGLPHSLSGRMYYSCEGTEPTLSDCFWRFNNSNLCRQSQAARVLCSGSRSLLNLSSSEAPTSVQPLTVESSVMMNTEDWESRELMLLILCIVLGVLLLGSFITIAFIFLKVKGKYALPVMANHEHLPTTTPAGINSYQDVPITISTKEVPNLPVQVQNPPPEDSDSSLDSDYEPYDFSAQPPVALTTFYNSQRHRPTDEEIQQSRFQMPPLEEGLEEMHASQVPPANPGHCIADAPSLGPQHHPRTKSGSSTSSGEGYCNNPSGRLPLWNPQAFSAEKTPFLEPPPNLELAGSQTTFSAGRSADDSSSTSSGEWYQNFQPPPQPPPEEQLEYPAPPSPQSESTSEDYDDIGAA","proteome":"UP000694387","gene":"CD6","go_terms":[{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ad5231f48af488f1e85b5e6e61a947e22a6b3e67","counters":{"domain_architectures":2801,"entries":9,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"profile":1,"smart":1,"pfam":1,"panther":1,"prints":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":2801}}}