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{
    "metadata": {
        "accession": "A0A8C2ZIG9",
        "id": "A0A8C2ZIG9_CYCLU",
        "source_organism": {
            "taxId": "8103",
            "scientificName": "Cyclopterus lumpus",
            "fullName": "Cyclopterus lumpus (Lumpsucker)"
        },
        "name": "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16",
        "description": [
            "Required for pre-mRNA splicing as a component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA. Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses"
        ],
        "length": 1047,
        "sequence": "MANLEQWVNDRLHDILGMSDRYVSQFMIGTARKSSSSQDFVTRLEETGTIDIEPSVVAFAQELFDKIPRKQVVEKPSRAMEREAIEMDKKNRTYTLLEDSDSDGEAVREKEKGKNKKDKDKGNRRKNFRKKKVSESSSEDEPPKSIVIMVEQKQEEEEEWEKEERERQHDIEERDAFAERVKQKDKDKTRNITERTDKKAYEEAQKRLKMAEDDQKNMLPELRKRSRWDYLKKREAEKLEDLEAEINDDEYLFHTEELTEREKKELDYKRTLRDLAKDYKKAGVKEHEERKNRYYMPEEKRNKEVPQRDLELEETPMELGGEQGRWEEERLKTASLSFGAKREREQGMKQEQERYQLILEEDEMIEFVSTAMTMKGTRSEKDQEALALSQAALKKESMQEVRRSLPIFPYREDLLAAINQHQILVIEGETGSGKTTQIPQYLLEDGYTKGGMKIGCTQPRRVAAMSVAARVAQEMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLTEPDLASYSVIIIDEAHERTLHTDILFGLIKDIARFRSDLKVLVASATLDTERFSCFFDDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQPTGDVLVFLTGQEEIETCCELLQERCRRLGSKIAELMVLPIYANLPSDMQAKIFNPTPLGARKVVVATNIAETSLTIDGIIYVIDPGFCKQKSYNARTGMESLIVTPCSRASANQRAGRAGRVAAGKCFRLYTAWAFKHEMEESTVPEIQRTNLGNVVLLLKSLGINDLIHFDFMDPPPHETLVLALEQLYALGALNHLGELTKLGRRMAELPVDPMLSKMILASEQYKCSEEVLTIAAMLSVNNSIFYRPKDKVVHADNARMNFVVPGGDHLVLLNVYTQWLESDYSTQWCYENFIQFRSMRRARDVRDQLEGLMDRIEVEVVSSQGDSLPIRKAVTAGYFYHTARLSKGGYKTVKHQQTVYVHPNSCLFEEQPRWLIYHELVFTTKEFMRQVIEIDSGWLLEVAPHYYKSKELEDSSSKKMPRKQGKAKEELG",
        "proteome": "UP000694565",
        "gene": "dhx16",
        "go_terms": [
            {
                "identifier": "GO:0003676",
                "name": "nucleic acid binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005524",
                "name": "ATP binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "7c6cf13eb36e25acc2433da48d728d3239183bee",
        "counters": {
            "domain_architectures": 17433,
            "entries": 25,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 5,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "ssf": 1,
                "smart": 3,
                "cdd": 2,
                "pfam": 5,
                "profile": 2,
                "panther": 1,
                "prosite": 1,
                "interpro": 8
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 17433
        }
    }
}