{"metadata":{"accession":"A0A8C2ZIG9","id":"A0A8C2ZIG9_CYCLU","source_organism":{"taxId":"8103","scientificName":"Cyclopterus lumpus","fullName":"Cyclopterus lumpus (Lumpsucker)"},"name":"Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16","description":["Required for pre-mRNA splicing as a component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA. Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses"],"length":1047,"sequence":"MANLEQWVNDRLHDILGMSDRYVSQFMIGTARKSSSSQDFVTRLEETGTIDIEPSVVAFAQELFDKIPRKQVVEKPSRAMEREAIEMDKKNRTYTLLEDSDSDGEAVREKEKGKNKKDKDKGNRRKNFRKKKVSESSSEDEPPKSIVIMVEQKQEEEEEWEKEERERQHDIEERDAFAERVKQKDKDKTRNITERTDKKAYEEAQKRLKMAEDDQKNMLPELRKRSRWDYLKKREAEKLEDLEAEINDDEYLFHTEELTEREKKELDYKRTLRDLAKDYKKAGVKEHEERKNRYYMPEEKRNKEVPQRDLELEETPMELGGEQGRWEEERLKTASLSFGAKREREQGMKQEQERYQLILEEDEMIEFVSTAMTMKGTRSEKDQEALALSQAALKKESMQEVRRSLPIFPYREDLLAAINQHQILVIEGETGSGKTTQIPQYLLEDGYTKGGMKIGCTQPRRVAAMSVAARVAQEMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLTEPDLASYSVIIIDEAHERTLHTDILFGLIKDIARFRSDLKVLVASATLDTERFSCFFDDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQPTGDVLVFLTGQEEIETCCELLQERCRRLGSKIAELMVLPIYANLPSDMQAKIFNPTPLGARKVVVATNIAETSLTIDGIIYVIDPGFCKQKSYNARTGMESLIVTPCSRASANQRAGRAGRVAAGKCFRLYTAWAFKHEMEESTVPEIQRTNLGNVVLLLKSLGINDLIHFDFMDPPPHETLVLALEQLYALGALNHLGELTKLGRRMAELPVDPMLSKMILASEQYKCSEEVLTIAAMLSVNNSIFYRPKDKVVHADNARMNFVVPGGDHLVLLNVYTQWLESDYSTQWCYENFIQFRSMRRARDVRDQLEGLMDRIEVEVVSSQGDSLPIRKAVTAGYFYHTARLSKGGYKTVKHQQTVYVHPNSCLFEEQPRWLIYHELVFTTKEFMRQVIEIDSGWLLEVAPHYYKSKELEDSSSKKMPRKQGKAKEELG","proteome":"UP000694565","gene":"dhx16","go_terms":[{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"7c6cf13eb36e25acc2433da48d728d3239183bee","counters":{"domain_architectures":17433,"entries":25,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":1,"smart":3,"cdd":2,"pfam":5,"profile":2,"panther":1,"prosite":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":17433}}}