General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "A0A7N4PSS5",
        "id": "A0A7N4PSS5_SARHA",
        "source_organism": {
            "taxId": "9305",
            "scientificName": "Sarcophilus harrisii",
            "fullName": "Sarcophilus harrisii (Tasmanian devil)"
        },
        "name": "Protein adenylyltransferase FICD",
        "description": [
            "Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context. The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place. Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP. In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it. In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity. Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates"
        ],
        "length": 453,
        "sequence": "MTFMSMATVVAVAEPKWVSLWGRWFWVAALLGLLLGSLLVVLLPLGAVEEQCSTLQKGLSLLRSKLGGGQKSPSTGLAVTTGGISLLVVKPKASADVKLEARAALNQALEMKRQGKREKAHRLFLHALKMDPNYVDALNELGIFSEEEKDILQADYLYTKALTISPYNEKALINRDRTLPLVEEIDQRYFSIIDSKVKKVMSIPKGSSALRRVMEESYYHHIYHTVAIEGNTLTLSEIRHIIETRYAVPGKSLEEQNEVIGMHAAMKYINTTLVSRIGSVTISDMLEIHRRVLGYVDPVEAGRFRTTQVFVGHHIPPHPHDVEKQMEEFIQWLNSEDAMNLHPVEFAALAHYKLVYIHPFIDGNGRTSRLLMNLILMQAGYPPITIRKEQRSEYYHVLEVANEGDVRPFIRFIAKCTETTLDMLLIATTDHAVGLPEANPNHSGCKQTIPVKT",
        "proteome": "UP000007648",
        "gene": "FICD",
        "go_terms": [
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "f0655f365fece0e681b6b55b3fb5057fd5260564",
        "counters": {
            "domain_architectures": 38263,
            "entries": 14,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 0,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "smart": 1,
                "profile": 2,
                "ssf": 2,
                "panther": 1,
                "pfam": 1,
                "interpro": 5
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 38263
        }
    }
}