{"metadata":{"accession":"A0A7N4PSS5","id":"A0A7N4PSS5_SARHA","source_organism":{"taxId":"9305","scientificName":"Sarcophilus harrisii","fullName":"Sarcophilus harrisii (Tasmanian devil)"},"name":"Protein adenylyltransferase FICD","description":["Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context. The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place. Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP. In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it. In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity. Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates"],"length":453,"sequence":"MTFMSMATVVAVAEPKWVSLWGRWFWVAALLGLLLGSLLVVLLPLGAVEEQCSTLQKGLSLLRSKLGGGQKSPSTGLAVTTGGISLLVVKPKASADVKLEARAALNQALEMKRQGKREKAHRLFLHALKMDPNYVDALNELGIFSEEEKDILQADYLYTKALTISPYNEKALINRDRTLPLVEEIDQRYFSIIDSKVKKVMSIPKGSSALRRVMEESYYHHIYHTVAIEGNTLTLSEIRHIIETRYAVPGKSLEEQNEVIGMHAAMKYINTTLVSRIGSVTISDMLEIHRRVLGYVDPVEAGRFRTTQVFVGHHIPPHPHDVEKQMEEFIQWLNSEDAMNLHPVEFAALAHYKLVYIHPFIDGNGRTSRLLMNLILMQAGYPPITIRKEQRSEYYHVLEVANEGDVRPFIRFIAKCTETTLDMLLIATTDHAVGLPEANPNHSGCKQTIPVKT","proteome":"UP000007648","gene":"FICD","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"f0655f365fece0e681b6b55b3fb5057fd5260564","counters":{"domain_architectures":38263,"entries":14,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"smart":1,"profile":2,"ssf":2,"panther":1,"pfam":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":38263}}}