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{
"metadata": {
"accession": "A0A7K7K824",
"id": "A0A7K7K824_AGEPH",
"source_organism": {
"taxId": "39638",
"scientificName": "Agelaius phoeniceus",
"fullName": "Agelaius phoeniceus (Red-winged blackbird)"
},
"name": "Ribonuclease 3",
"description": [
"Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons"
],
"length": 1337,
"sequence": "MSFHSGRGCPRGQGGPGARTSAQTYRPQNLRQLHPQQPSVQYQYEQQTAPPTTYSNPPATGYMPPRPDFVPYPPPVPPSTQNPISQCPMRPPFPNHQMRQSFPVPPCFPPTPPPVPNPSNTPVPGTPAGQSTFPYMMPPPTVPHPPPPPVMPQQVSYQPVYSAGYSQQSFPPPSFNSYQHSSGSFPSSTASSSAGSSHFRHTGQYQGEKSQSERRSPDRSKHYDEHRHREHGHMHGDRHRSANHGDRRDRGRSPDRRRQESSRHRTDYDRGRISPHHRSYERNRERERERHRHRDSRRSPSPDRSYKKDYKRAGSRSPSRERKRTRWEEDRERWSENQSSSKEKNYTAVKDKESEENASEKNEEEDEELLKPVWVRCTHSESYYSNDPMDQVGDSTVVGTSKLRDLYEKFDEELGKRQAKAKAARPPWEPPKTKLDEDLESSSESECDSEDDSSCSSSSDSDVIDVIAEIKRKKAHPDRLHEELWYNDPGQMNDGPLCKCSAKARRTGIRHGIYPGEEPIKPCRPMTNNAGRLYHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVRGLELFSSYLFKDILELYDWNLKGSPSLENDSISCPRYHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTSPGMKPSSVRIDQLDREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQADKQKLSQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHVRYHQCLMHLDKLIGYTFRDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHIHMRKKGINTLINIMSRLGQDDPAPSRINHNERLEFLGDAVVEFLTSVHLYYLFPTLEEGGLATYRTAIVQNQHLAMLAKKLELERFMLYAHGPDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNEKDLRDVWLNYPLHPLQLQESNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEFAITNDKTKRPVTLRTKTLADLLESFIAALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQAEMGAAMDALEKYNFPQMAHQKRFIERKYRQELKELRWEREHQERESEETEEARK",
"proteome": "UP000521525",
"gene": "Drosha",
"go_terms": [
{
"identifier": "GO:0004525",
"name": "ribonuclease III activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006396",
"name": "RNA processing",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0003723",
"name": "RNA binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0031054",
"name": "pre-miRNA processing",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0006364",
"name": "rRNA processing",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"protein_evidence": 3,
"source_database": "unreviewed",
"is_fragment": true,
"in_alphafold": false,
"in_bfvd": false,
"ida_accession": "13d696ea62f16b0c465f357f1e5c295c85b0b3c8",
"counters": {
"domain_architectures": 1833,
"entries": 23,
"isoforms": 0,
"proteomes": 1,
"sets": 4,
"structures": 0,
"taxa": 1,
"dbEntries": {
"pfam": 4,
"ssf": 2,
"cathgene3d": 2,
"profile": 2,
"smart": 2,
"cdd": 2,
"panther": 1,
"hamap": 1,
"prosite": 1,
"interpro": 6
},
"proteome": 1,
"taxonomy": 1,
"similar_proteins": 1833
}
}
}
