{"metadata":{"accession":"A0A7K7K824","id":"A0A7K7K824_AGEPH","source_organism":{"taxId":"39638","scientificName":"Agelaius phoeniceus","fullName":"Agelaius phoeniceus (Red-winged blackbird)"},"name":"Ribonuclease 3","description":["Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons"],"length":1337,"sequence":"MSFHSGRGCPRGQGGPGARTSAQTYRPQNLRQLHPQQPSVQYQYEQQTAPPTTYSNPPATGYMPPRPDFVPYPPPVPPSTQNPISQCPMRPPFPNHQMRQSFPVPPCFPPTPPPVPNPSNTPVPGTPAGQSTFPYMMPPPTVPHPPPPPVMPQQVSYQPVYSAGYSQQSFPPPSFNSYQHSSGSFPSSTASSSAGSSHFRHTGQYQGEKSQSERRSPDRSKHYDEHRHREHGHMHGDRHRSANHGDRRDRGRSPDRRRQESSRHRTDYDRGRISPHHRSYERNRERERERHRHRDSRRSPSPDRSYKKDYKRAGSRSPSRERKRTRWEEDRERWSENQSSSKEKNYTAVKDKESEENASEKNEEEDEELLKPVWVRCTHSESYYSNDPMDQVGDSTVVGTSKLRDLYEKFDEELGKRQAKAKAARPPWEPPKTKLDEDLESSSESECDSEDDSSCSSSSDSDVIDVIAEIKRKKAHPDRLHEELWYNDPGQMNDGPLCKCSAKARRTGIRHGIYPGEEPIKPCRPMTNNAGRLYHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVRGLELFSSYLFKDILELYDWNLKGSPSLENDSISCPRYHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTSPGMKPSSVRIDQLDREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQADKQKLSQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHVRYHQCLMHLDKLIGYTFRDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHIHMRKKGINTLINIMSRLGQDDPAPSRINHNERLEFLGDAVVEFLTSVHLYYLFPTLEEGGLATYRTAIVQNQHLAMLAKKLELERFMLYAHGPDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNEKDLRDVWLNYPLHPLQLQESNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEFAITNDKTKRPVTLRTKTLADLLESFIAALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQAEMGAAMDALEKYNFPQMAHQKRFIERKYRQELKELRWEREHQERESEETEEARK","proteome":"UP000521525","gene":"Drosha","go_terms":[{"identifier":"GO:0004525","name":"ribonuclease III activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006396","name":"RNA processing","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0031054","name":"pre-miRNA processing","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006364","name":"rRNA processing","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":true,"in_alphafold":false,"in_bfvd":false,"ida_accession":"13d696ea62f16b0c465f357f1e5c295c85b0b3c8","counters":{"domain_architectures":1833,"entries":23,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"pfam":4,"ssf":2,"cathgene3d":2,"profile":2,"smart":2,"cdd":2,"panther":1,"hamap":1,"prosite":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":1833}}}