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{
    "metadata": {
        "accession": "A0A6P8PNZ4",
        "id": "A0A6P8PNZ4_GEOSA",
        "source_organism": {
            "taxId": "260995",
            "scientificName": "Geotrypetes seraphini",
            "fullName": "Geotrypetes seraphini (Gaboon caecilian)"
        },
        "name": "Lymphocyte cytosolic protein 2",
        "description": [
            "Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells. Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK. In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation. Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses"
        ],
        "length": 527,
        "sequence": "MDFRNVSSRSEVIAWSPDALADYFHMINMNDCEKVVRKHNISGQRFLNMAENNFQKFPQIRVPLLSKLCQEINKKDERRSLFNRRTPVHKIPNEKEFKQDDDGWSSFEDDDDYESPTEEQYFEDDEADYESPTEDPMENGSDSLDYEPPPTNNEDAHSNIISPACFSSDSGYIDRPTTVSSSQHPPLPPQRHGPLLLPPVAGIRLPTIPLSSQFNDISSGRSVRHSKPPPPVVDRTKKPPFVYPGAPNPDRDYIPQGKKLPFPEVPMPPPPRSSIDKCVDHSTRIQRPPLSTERNNAFVESRPRRSVWPGNQKTDEEEGLQRPIPQPVITHYSSNTFPSTKMNKNLPRAPLCGVNTESKHSSGSLPPRIPPSNISRSFSEGPANFRPMLPPPNKHMVSSTPMTEDECIEHQDWYAGEMNRPEAEDALMMVNQDGAFLVRNSSKRSTSHPYVLMVLYKNKVYNIQIRYDEKDNIYLLGTGLRGKENFSSVADIIDHFRRTPLLLIDGRDRGSKNQCMLTYAAAAVQDF",
        "proteome": "UP000515159",
        "gene": "LCP2",
        "go_terms": null,
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "8797a2809872b61a223c5f69e3b5d4c1858c033a",
        "counters": {
            "domain_architectures": 22787,
            "entries": 14,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "ssf": 2,
                "cdd": 1,
                "smart": 1,
                "pfam": 1,
                "profile": 1,
                "panther": 1,
                "prints": 1,
                "interpro": 4
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 22787
        }
    }
}