{"metadata":{"accession":"A0A6P8PNZ4","id":"A0A6P8PNZ4_GEOSA","source_organism":{"taxId":"260995","scientificName":"Geotrypetes seraphini","fullName":"Geotrypetes seraphini (Gaboon caecilian)"},"name":"Lymphocyte cytosolic protein 2","description":["Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells. Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK. In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation. Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses"],"length":527,"sequence":"MDFRNVSSRSEVIAWSPDALADYFHMINMNDCEKVVRKHNISGQRFLNMAENNFQKFPQIRVPLLSKLCQEINKKDERRSLFNRRTPVHKIPNEKEFKQDDDGWSSFEDDDDYESPTEEQYFEDDEADYESPTEDPMENGSDSLDYEPPPTNNEDAHSNIISPACFSSDSGYIDRPTTVSSSQHPPLPPQRHGPLLLPPVAGIRLPTIPLSSQFNDISSGRSVRHSKPPPPVVDRTKKPPFVYPGAPNPDRDYIPQGKKLPFPEVPMPPPPRSSIDKCVDHSTRIQRPPLSTERNNAFVESRPRRSVWPGNQKTDEEEGLQRPIPQPVITHYSSNTFPSTKMNKNLPRAPLCGVNTESKHSSGSLPPRIPPSNISRSFSEGPANFRPMLPPPNKHMVSSTPMTEDECIEHQDWYAGEMNRPEAEDALMMVNQDGAFLVRNSSKRSTSHPYVLMVLYKNKVYNIQIRYDEKDNIYLLGTGLRGKENFSSVADIIDHFRRTPLLLIDGRDRGSKNQCMLTYAAAAVQDF","proteome":"UP000515159","gene":"LCP2","go_terms":null,"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"8797a2809872b61a223c5f69e3b5d4c1858c033a","counters":{"domain_architectures":20499,"entries":14,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"cdd":1,"smart":1,"pfam":1,"profile":1,"panther":1,"prints":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":20499}}}