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{
    "metadata": {
        "accession": "A0A6J3RTP1",
        "id": "A0A6J3RTP1_TURTR",
        "source_organism": {
            "taxId": "9739",
            "scientificName": "Tursiops truncatus",
            "fullName": "Tursiops truncatus (Atlantic bottle-nosed dolphin)"
        },
        "name": "NLR family member X1",
        "description": [
            "Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species. Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner. In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases"
        ],
        "length": 965,
        "sequence": "MRWGCHLPRASWGPGLGRVLQPADERIPFLIHWSWPLKGERPLGPPRAFIRHHGSSAGSGPPSGRHGQLFQGIAAAEAIQRHRQNLAEWFSRLPREERQFGPTFALDTVHVDPVIRESTPDELLRPLAELALEHQPPSAGLPPLALSQLFDPDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGQLPAFKLLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEILPLMAAAGSCLLFVLHGLEHLNLDFRLAGTGLCSDPEESEAPAAIIVNLLRKYMLPEASILVTTRPSAIGRIPSKYVDRYGEICGFSDTNLQKLYFQLRFKQPDCGHGAGGFSATPAQRDHLVQMLSRNLEGHHQIATACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLHLNFSGEMLDSTDPSKLSLMAYAARTMGKLAYEGVSSRKTYFSEEDVRGCLEAGIQTEEEFQLLHVFRRDALRFFLAPCVEPGHLGTFVFTVPAMQEYLAALYIVLGLRKTTLQRVGKEVAELMSRVGEDVSLVLGIMAKLLPLRALPLLFNLLKVVPRVFGRVVGKSRETVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRCRSDEPTEDEVFELFPMFMGGLLSAHNRVVLAQLGCPIKTLDALENAQAIKKKLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRMTPLKCMVVAAVLGSGRHALDEVNFASCQLDPAGLRTLRPVFLRARKLGLQLNSLGPEACRDLRDLLLHDQCQVTTLRLSNNPLTAAGVALLVEGLAGNTSLKHLSLLHTGLGDEGLELLAAQLDRNQQLQELNVAYNGAGDTAALALAKAAREHPSLELLHLYFNELSSECRQALRDLGSTTEGGARVVVSLTEGTAVSEYWSVILGEVQRNLNSWDRGRVRRHLELLLRDLEDNRGATLNPWRKAQLLRVEGEMFLGH",
        "proteome": "UP000245320",
        "gene": "NLRX1",
        "go_terms": [
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "49a367d208388fe119714b12f26d45dc272dcfd0",
        "counters": {
            "domain_architectures": 345,
            "entries": 15,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "profile": 1,
                "pfam": 3,
                "ssf": 1,
                "smart": 1,
                "panther": 1,
                "interpro": 6
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 345
        }
    }
}