{"metadata":{"accession":"A0A6J3RTP1","id":"A0A6J3RTP1_TURTR","source_organism":{"taxId":"9739","scientificName":"Tursiops truncatus","fullName":"Tursiops truncatus (Atlantic bottle-nosed dolphin)"},"name":"NLR family member X1","description":["Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species. Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner. In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases"],"length":965,"sequence":"MRWGCHLPRASWGPGLGRVLQPADERIPFLIHWSWPLKGERPLGPPRAFIRHHGSSAGSGPPSGRHGQLFQGIAAAEAIQRHRQNLAEWFSRLPREERQFGPTFALDTVHVDPVIRESTPDELLRPLAELALEHQPPSAGLPPLALSQLFDPDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGQLPAFKLLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEILPLMAAAGSCLLFVLHGLEHLNLDFRLAGTGLCSDPEESEAPAAIIVNLLRKYMLPEASILVTTRPSAIGRIPSKYVDRYGEICGFSDTNLQKLYFQLRFKQPDCGHGAGGFSATPAQRDHLVQMLSRNLEGHHQIATACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLHLNFSGEMLDSTDPSKLSLMAYAARTMGKLAYEGVSSRKTYFSEEDVRGCLEAGIQTEEEFQLLHVFRRDALRFFLAPCVEPGHLGTFVFTVPAMQEYLAALYIVLGLRKTTLQRVGKEVAELMSRVGEDVSLVLGIMAKLLPLRALPLLFNLLKVVPRVFGRVVGKSRETVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRCRSDEPTEDEVFELFPMFMGGLLSAHNRVVLAQLGCPIKTLDALENAQAIKKKLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRMTPLKCMVVAAVLGSGRHALDEVNFASCQLDPAGLRTLRPVFLRARKLGLQLNSLGPEACRDLRDLLLHDQCQVTTLRLSNNPLTAAGVALLVEGLAGNTSLKHLSLLHTGLGDEGLELLAAQLDRNQQLQELNVAYNGAGDTAALALAKAAREHPSLELLHLYFNELSSECRQALRDLGSTTEGGARVVVSLTEGTAVSEYWSVILGEVQRNLNSWDRGRVRRHLELLLRDLEDNRGATLNPWRKAQLLRVEGEMFLGH","proteome":"UP000245320","gene":"NLRX1","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"49a367d208388fe119714b12f26d45dc272dcfd0","counters":{"domain_architectures":345,"entries":15,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"profile":1,"pfam":3,"ssf":1,"smart":1,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":345}}}