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InterPro-Version: 108.0
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{
"metadata": {
"accession": "A0A6J2FP26",
"id": "A0A6J2FP26_ZALCA",
"source_organism": {
"taxId": "9704",
"scientificName": "Zalophus californianus",
"fullName": "Zalophus californianus (California sealion)"
},
"name": "Dual specificity protein phosphatase 3",
"description": [
"Participates in cell spreading through the phosphoinositide-3-kinase (PI3K) pathway by connecting CADM1 to DLG1 and the regulatory subunit of phosphoinositide-3-kinase (PI3K). Stabilizes HTR2C at the plasma membrane and prevents its desensitization. May participates in the maintenance of adherens junctions",
"Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2"
],
"length": 741,
"sequence": "MPVLSEDSGLHETLALLTSQLRPDSNHKEEMGFLRDVFSEKSLGYLMKIHEKLRYYERQSPTPVLHSAVALAEDVMEELQAASVHSDERELLQLLSTPHLRAMLMVHDTVAQKNFDPVLPPLPDNIDEDFDEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPDEISQILAQSQGAITLKIIPATQEEDRLKDSKVFMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKRFQERRLSYRRATGTLPSPQSLRKPPYDQPCDKETCDCEGYFKGHYVAGLRRSFRLGRRERPGSPQEGKGSAGAEAPELLTYEEVTRYQHQPGERPRLVVLIGSLGARLHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVSKQAFEADLHHNKFLEHGEYKENLYGTSLDAIQEVMAKNKVCLVDVEPDALQQLRTSEFKPYVIFVKPAIQEKRKTPPMSPACEDTAAPCMKNLKSKAIACSAAQEPSCCPAVQGPAAAMSGPFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNEKLVKEGKLKL",
"proteome": "UP000515165",
"gene": "LOC113939572",
"go_terms": [
{
"identifier": "GO:0005515",
"name": "protein binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006470",
"name": "protein dephosphorylation",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0016311",
"name": "dephosphorylation",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0008138",
"name": "protein tyrosine/serine/threonine phosphatase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"protein_evidence": 3,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": true,
"in_bfvd": false,
"ida_accession": "8a18531b9b81594b9fb281d770f0ea43d91803d8",
"counters": {
"domain_architectures": 3,
"entries": 54,
"isoforms": 0,
"proteomes": 1,
"sets": 8,
"structures": 0,
"taxa": 1,
"dbEntries": {
"profile": 6,
"smart": 5,
"pfam": 5,
"cathgene3d": 5,
"ssf": 5,
"cdd": 4,
"panther": 1,
"prosite": 2,
"prints": 2,
"interpro": 19
},
"proteome": 1,
"taxonomy": 1,
"similar_proteins": 3
}
}
}