{"metadata":{"accession":"A0A6J2FP26","id":"A0A6J2FP26_ZALCA","source_organism":{"taxId":"9704","scientificName":"Zalophus californianus","fullName":"Zalophus californianus (California sealion)"},"name":"Dual specificity protein phosphatase 3","description":["Participates in cell spreading through the phosphoinositide-3-kinase (PI3K) pathway by connecting CADM1 to DLG1 and the regulatory subunit of phosphoinositide-3-kinase (PI3K). Stabilizes HTR2C at the plasma membrane and prevents its desensitization. May participates in the maintenance of adherens junctions","Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2"],"length":741,"sequence":"MPVLSEDSGLHETLALLTSQLRPDSNHKEEMGFLRDVFSEKSLGYLMKIHEKLRYYERQSPTPVLHSAVALAEDVMEELQAASVHSDERELLQLLSTPHLRAMLMVHDTVAQKNFDPVLPPLPDNIDEDFDEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPDEISQILAQSQGAITLKIIPATQEEDRLKDSKVFMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKRFQERRLSYRRATGTLPSPQSLRKPPYDQPCDKETCDCEGYFKGHYVAGLRRSFRLGRRERPGSPQEGKGSAGAEAPELLTYEEVTRYQHQPGERPRLVVLIGSLGARLHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVSKQAFEADLHHNKFLEHGEYKENLYGTSLDAIQEVMAKNKVCLVDVEPDALQQLRTSEFKPYVIFVKPAIQEKRKTPPMSPACEDTAAPCMKNLKSKAIACSAAQEPSCCPAVQGPAAAMSGPFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNEKLVKEGKLKL","proteome":"UP000515165","gene":"LOC113939572","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006470","name":"protein dephosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016311","name":"dephosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008138","name":"protein tyrosine/serine/threonine phosphatase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"8a18531b9b81594b9fb281d770f0ea43d91803d8","counters":{"domain_architectures":3,"entries":54,"isoforms":0,"proteomes":1,"sets":8,"structures":0,"taxa":1,"dbEntries":{"profile":6,"smart":5,"pfam":5,"cathgene3d":5,"ssf":5,"cdd":4,"panther":1,"prosite":2,"prints":2,"interpro":19},"proteome":1,"taxonomy":1,"similar_proteins":3}}}