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InterPro-Version: 108.0
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{
"metadata": {
"accession": "A0A6I8NFF9",
"id": "A0A6I8NFF9_ORNAN",
"source_organism": {
"taxId": "9258",
"scientificName": "Ornithorhynchus anatinus",
"fullName": "Ornithorhynchus anatinus (Duckbill platypus)"
},
"name": "Signal transducing adaptor molecule",
"description": [
"Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes"
],
"length": 510,
"sequence": "MIILLYEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMKRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVATKKEEEDLAKAIELSLKEQRQQSTTVSSLYPSTSSLLTNHHPEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETLQGMGLFPSNFVTADLSAEPEMMKTEKKTVQFSDDIQVETIEPEPEPAYIDEDKMDQLLQMLQSADPSDDQPDIPDLLHLEAICHQMGPLIDEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQSQGYYMQSPGVSGSQVYPGQAPSGIYLVTGSAQMGSVQSYSVPPDQLSSLSHAAAPPPASSALPAQQAQASYTNPVVGSVPGNTYPNQTAIYSPPADVTAYQNAGTSMSQGPNYSLASSTPSQPRNENA",
"proteome": "UP000002279",
"gene": "STAM",
"go_terms": [
{
"identifier": "GO:0035091",
"name": "phosphatidylinositol binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0043130",
"name": "ubiquitin binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0005515",
"name": "protein binding",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"protein_evidence": 3,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": true,
"in_bfvd": false,
"ida_accession": "e0390835bbf30b88a8a62d90f55768a3fdc95672",
"counters": {
"domain_architectures": 2360,
"entries": 29,
"isoforms": 0,
"proteomes": 1,
"sets": 6,
"structures": 0,
"taxa": 1,
"dbEntries": {
"smart": 2,
"cathgene3d": 4,
"cdd": 3,
"pfam": 3,
"ssf": 2,
"profile": 3,
"panther": 1,
"prints": 2,
"interpro": 9
},
"proteome": 1,
"taxonomy": 1,
"similar_proteins": 2360
}
}
}