{"metadata":{"accession":"A0A6I8NFF9","id":"A0A6I8NFF9_ORNAN","source_organism":{"taxId":"9258","scientificName":"Ornithorhynchus anatinus","fullName":"Ornithorhynchus anatinus (Duckbill platypus)"},"name":"Signal transducing adaptor molecule","description":["Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes"],"length":510,"sequence":"MIILLYEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMKRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVATKKEEEDLAKAIELSLKEQRQQSTTVSSLYPSTSSLLTNHHPEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETLQGMGLFPSNFVTADLSAEPEMMKTEKKTVQFSDDIQVETIEPEPEPAYIDEDKMDQLLQMLQSADPSDDQPDIPDLLHLEAICHQMGPLIDEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQSQGYYMQSPGVSGSQVYPGQAPSGIYLVTGSAQMGSVQSYSVPPDQLSSLSHAAAPPPASSALPAQQAQASYTNPVVGSVPGNTYPNQTAIYSPPADVTAYQNAGTSMSQGPNYSLASSTPSQPRNENA","proteome":"UP000002279","gene":"STAM","go_terms":[{"identifier":"GO:0035091","name":"phosphatidylinositol binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0043130","name":"ubiquitin binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e0390835bbf30b88a8a62d90f55768a3fdc95672","counters":{"domain_architectures":2360,"entries":29,"isoforms":0,"proteomes":1,"sets":6,"structures":0,"taxa":1,"dbEntries":{"smart":2,"cathgene3d":4,"cdd":3,"pfam":3,"ssf":2,"profile":3,"panther":1,"prints":2,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":2360}}}