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{
    "metadata": {
        "accession": "A0A665U8Z6",
        "id": "A0A665U8Z6_ECHNA",
        "source_organism": {
            "taxId": "173247",
            "scientificName": "Echeneis naucrates",
            "fullName": "Echeneis naucrates (Live sharksucker)"
        },
        "name": "NADPH oxidase 4",
        "description": [
            "NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2. Can also catalyze to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release"
        ],
        "length": 527,
        "sequence": "MAVSLRSWVANEGGKHLVLMLWVGTNIWLFLKTFLLYSSGQQYHYLYKMLGLGLCISRASASVLNLNCSLVLLPMCRSLLTFVRGTDTVSSRKTRRLLDKSKTFHVACGVTICIFSVVHVSAHLVNVLNFSVSYSDDFPALNLALPGVTGVLLTLILFLMFMSSSYSNIRLIHVFTTSGALKYQTNIDAHPPGCLRANQSSTGSQGKELDRGEDEEQRCREEAHFQPHYPQTWLWVSGPLCLYCAERFYRYVRSSDPVTIVTVIKHPCDVFELRMLKKNFRARPGQYILLNCPNVSSFENHPFTLTTCPTENKETFGIHLRVVGDWTGRFTEMLLPQPRIGLDVLPMLQQRRYPKLYVDGPFGSPSEEVFNYDVSLCVAGGIGVTPFACVLHALLDGWTGFRLQRLYFVWVCRELQSFYWFAELLCALHHKLWQENRPDYFNLRLYLSRADGLQSMPEEKYRPLASRLLVGRPRWKLLFDEIGKTNKDKRVGVFCCGPKGISRTLHRLCNSGRSSGATFEFNKESFS",
        "proteome": "UP000472264",
        "gene": "nox4",
        "go_terms": [
            {
                "identifier": "GO:0016491",
                "name": "oxidoreductase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "496ce31aafc2f777618f119f81f7277d9a382e44",
        "counters": {
            "domain_architectures": 22735,
            "entries": 17,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 4,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "pfam": 3,
                "profile": 1,
                "cathgene3d": 2,
                "ssf": 2,
                "cdd": 1,
                "panther": 1,
                "interpro": 7
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 22735
        }
    }
}